Correlation between Electrodiagnostic Findings and Cerebrospinal Fluid Changes in Children with Guillain-Barre syndrome.

IF 0.8 Q4 CLINICAL NEUROLOGY
Iranian Journal of Child Neurology Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI:10.22037/ijcn.v19i1.44703
Maryam Noory, Kambiz Eftekhari, Hosein Shabani-Mirzaee, Mohammad Barzegar, Armen Malekiantaghi
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引用次数: 0

Abstract

Objectives: Guillain-Barré syndrome (GBS) involves the peripheral nervous system developed by infections or immune conditions. Cerebrospinal fluid (CSF) analysis and electrodiagnostic tests are essential diagnostic methods for GBS. However, limited data are available on how the findings from these methods relate to each other. This study aimed to evaluate changes in CSF analysis and electrodiagnostic tests in pediatrics with GBS.

Materials & methods: The present study retrospectively evaluated electrodiagnostic tests and CSF changes in pediatrics with GBS who were admitted to Tabriz Hospital, Iran, from 2010 to 2020 due to CBS. Patients' data, including age, gender, CSF analysis, and electrodiagnostic test results, were recorded from the patients' files. Electrodiagnostic data included pace and amplitude of tibial, median, peroneal, sural, ulnar nerves, nerve conduction velocity (NCV), F-wave, and motor unit action potential (MUAP). The significance level was considered less than 0.05.

Results: The mean age of patients was 4.83±2.72 years, and 54.6% were boys. The most common type of GBS involvement was demyelinating type. No gender differences were found between involved nerves unless the ulnar nerve was significantly more involved in girls (P-value: 0.012). The obtained findings indicated no significant relationship between electrodiagnostic tests and CSF protein (P-value: 0.439).

Conclusion: No association was observed between electrodiagnostic results and CSF changes in pediatrics with GBS.

格林-巴利综合征患儿电诊断结果与脑脊液变化的相关性
目的:吉兰-巴罗综合征(GBS)累及周围神经系统,由感染或免疫条件发展。脑脊液(CSF)分析和电诊断试验是GBS的基本诊断方法。然而,关于这些方法的发现如何相互关联的数据有限。本研究旨在评估小儿GBS脑脊液分析和电诊断试验的变化。材料与方法:本研究回顾性评价2010 - 2020年因CBS在伊朗大不里士医院收治的GBS患儿的电诊断试验和CSF变化。患者的资料,包括年龄、性别、脑脊液分析和电诊断测试结果,从患者档案中记录。电诊断数据包括胫骨神经、正中神经、腓神经、腓肠神经、尺神经、神经传导速度(NCV)、f波和运动单位动作电位(MUAP)的速度和振幅。认为显著性水平小于0.05。结果:患者平均年龄4.83±2.72岁,男童占54.6%。最常见的GBS受累类型为脱髓鞘型。受累神经间无性别差异,但尺神经在女孩中受累较多(p值:0.012)。结果显示,电诊断试验与脑脊液蛋白无显著相关性(p值:0.439)。结论:小儿GBS的电诊断结果与脑脊液变化无相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
35
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