Unraveling the link between magnesium and diabetic neuropathy: Evidence from in vitro to clinical studies

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Research Pub Date : 2025-01-10 DOI:10.1016/j.nutres.2025.01.005

Kannika Smithiseth , Prangmalee Leurcharusmee , Passakorn Sawaddiruk , Nipon Chattipakorn , Siriporn Chattipakorn

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Abstract

Diabetic neuropathy (DN) is one of the major complications of diabetes and the most common cause of neuropathic pain. Although the underlying pathological mechanisms remain unclear, several studies have produced conflicting results regarding the link between magnesium (Mg) concentration and DN. This ambiguity raises questions about the potential benefits of Mg supplementation in individuals with DN. Therefore, this comprehensive review summarizes and discusses the evidence from clinical, in vitro, and in vivo studies on the association between Mg and DN. Several findings indicate that Mg depletion is linked to the presence of neuropathy in diabetic patients. Additionally, low Mg concentration may contribute to the onset or worsening of DN by promoting axonal degeneration through various pathways. Furthermore, multiple studies have shown that Mg supplementation can have neuroprotective effects. These findings suggest potential as an alternative or complementary therapy for preventing and treating DN in the future.

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揭示镁与糖尿病神经病变之间的联系：从体外到临床研究的证据。

糖尿病性神经病变（DN）是糖尿病的主要并发症之一，也是神经性疼痛的最常见原因。尽管潜在的病理机制尚不清楚，但关于镁（Mg）浓度与DN之间的联系，一些研究产生了相互矛盾的结果。这种模糊性引发了对DN患者补充Mg的潜在益处的质疑。因此，本文就Mg与DN之间关系的临床、体外和体内研究进行综述和讨论。一些研究结果表明，Mg的消耗与糖尿病患者神经病变的存在有关。此外，低Mg浓度可能通过多种途径促进轴突变性，从而促进DN的发生或恶化。此外，多项研究表明，补充镁具有神经保护作用。这些发现提示了未来预防和治疗DN的替代或补充疗法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Research 医学-营养学

CiteScore

7.60

自引率

2.20%

发文量

107

审稿时长

58 days

期刊介绍： Nutrition Research publishes original research articles, communications, and reviews on basic and applied nutrition. The mission of Nutrition Research is to serve as the journal for global communication of nutrition and life sciences research on diet and health. The field of nutrition sciences includes, but is not limited to, the study of nutrients during growth, reproduction, aging, health, and disease. Articles covering basic and applied research on all aspects of nutrition sciences are encouraged, including: nutritional biochemistry and metabolism; metabolomics, nutrient gene interactions; nutrient requirements for health; nutrition and disease; digestion and absorption; nutritional anthropology; epidemiology; the influence of socioeconomic and cultural factors on nutrition of the individual and the community; the impact of nutrient intake on disease response and behavior; the consequences of nutritional deficiency on growth and development, endocrine and nervous systems, and immunity; nutrition and gut microbiota; food intolerance and allergy; nutrient drug interactions; nutrition and aging; nutrition and cancer; obesity; diabetes; and intervention programs.