Modulation of Intestinal Flora: a Novel Immunotherapeutic Approach for Enhancing Thyroid Cancer Treatment.

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Probiotics and Antimicrobial Proteins Pub Date : 2025-06-01 Epub Date: 2025-01-31 DOI:10.1007/s12602-025-10471-z

Weiqiang Huang, Tao Jiang, Jiaxuan He, Jing Ruan, Baihui Wu, Runchao Tao, Peiye Xu, Yongpan Wang, Rongbing Chen, Hanbing Wang, Qinsi Yang, Kun Zhang, Libo Jin, Da Sun, Jinfeng You

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Abstract

Over the past 3 years, there has been a growing interest in clinical research regarding the potential involvement of intestinal flora in thyroid cancer (TC). This review delves into the intricate connection between intestinal flora and TC, focusing on the particular intestinal flora that is directly linked to the disease and identifying which may be able to predict potential microbial markers of TC. In order to shed light on the inflammatory pathways connected to the onset of TC, we investigated the impact of intestinal flora on immune modulation and the connection between chronic inflammation when investigating the role of intestinal flora in the pathogenesis of TC. Furthermore, the potential role of intestinal flora metabolites in the regulation of thyroid function was clarified by exploring the effects of short-chain fatty acids and lipopolysaccharide on thyroid hormone synthesis and metabolism. Based on these findings, we further explore the effects of probiotics, prebiotics, postbiotics, vitamins, and trace elements.

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调节肠道菌群：一种新的增强甲状腺癌治疗的免疫治疗方法。

在过去的三年中，人们对肠道菌群与甲状腺癌（TC）的潜在关系的临床研究越来越感兴趣。本文将深入探讨肠道菌群与TC之间的复杂联系，重点关注与该疾病直接相关的特定肠道菌群，并确定哪些可能能够预测TC的潜在微生物标志物。为了揭示与TC发病相关的炎症途径，我们在研究肠道菌群在TC发病中的作用时，研究了肠道菌群对免疫调节的影响以及慢性炎症之间的联系。此外，通过探讨短链脂肪酸和脂多糖对甲状腺激素合成和代谢的影响，阐明肠道菌群代谢物在调节甲状腺功能中的潜在作用。在此基础上，我们进一步探讨了益生菌、益生元、后益生菌、维生素和微量元素的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.