RNA methylation homeostasis in ocular diseases: All eyes on Me

IF 14.7 1区医学 Q1 OPHTHALMOLOGY

Progress in Retinal and Eye Research Pub Date : 2025-01-27 DOI:10.1016/j.preteyeres.2025.101335

Jieling Tang , Chuandi Zhou , Fuxiang Ye , Sipeng Zuo , Min Zhou , Linna Lu , Peiwei Chai , Xianqun Fan

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引用次数: 0

Abstract

RNA methylation is a pivotal epigenetic modification that adjusts various aspects of RNA biology, including nuclear transport, stability, and the efficiency of translation for specific RNA candidates. The methylation of RNA involves the addition of methyl groups to specific bases and can occur at different sites, resulting in distinct forms, such as N6-methyladenosine (m⁶A), N1-methyladenosine (m¹A), 5-methylcytosine (m⁵C), and 7-methylguanosine (m⁷G). Maintaining an optimal equilibrium of RNA methylation is crucial for fundamental cellular activities such as cell survival, proliferation, and migration. The balance of RNA methylation is linked to various pathophysiological conditions, including senescence, cancer development, stress responses, and blood vessel formation, all of which are pivotal for comprehending a spectrum of eye diseases.

Recent findings have highlighted the significant role of diverse RNA methylation patterns in ophthalmological conditions such as age-related macular degeneration, diabetic retinopathy, cataracts, glaucoma, uveitis, retinoblastoma, uveal melanoma, thyroid eye disease, and myopia, which are critical for vision health. This thorough review endeavors to dissect the influence of RNA methylation on common and vision-impairing ocular disorders. It explores the nuanced roles that RNA methylation plays in key pathophysiological mechanisms, such as oxidative stress and angiogenesis, which are integral to the onset and progression of these diseases. By synthesizing the latest research, this review offers valuable insights into how RNA methylation could be harnessed for therapeutic interventions in the field of ophthalmology.

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眼部疾病中的RNA甲基化稳态：所有人都在关注我。

RNA甲基化是一种关键的表观遗传修饰，可调节RNA生物学的各个方面，包括核转运、稳定性和特定RNA候选物的翻译效率。RNA的甲基化涉及到特定碱基的甲基化，可以发生在不同的位置，产生不同的形式，如n6 -甲基腺苷（m6A）， n1 -甲基腺苷（m1A）， 5-甲基胞嘧啶（m5C）和7-甲基鸟苷（m7G）。维持RNA甲基化的最佳平衡对于细胞生存、增殖和迁移等基本细胞活动至关重要。RNA甲基化的平衡与各种病理生理状况有关，包括衰老、癌症发展、应激反应和血管形成，所有这些都是理解一系列眼病的关键。最近的研究结果强调了不同RNA甲基化模式在眼科疾病中的重要作用，如年龄相关性黄斑变性、糖尿病视网膜病变、白内障、青光眼、葡萄膜炎、视网膜母细胞瘤、葡萄膜黑色素瘤、甲状腺眼病和近视，这些疾病对视力健康至关重要。这篇全面的综述努力剖析RNA甲基化对常见和视力损害的眼部疾病的影响。它探讨了RNA甲基化在关键病理生理机制中所起的微妙作用，如氧化应激和血管生成，这些机制是这些疾病发生和发展的组成部分。通过对最新研究的综合，本综述为如何利用RNA甲基化进行眼科领域的治疗干预提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Retinal and Eye Research 医学-眼科学

CiteScore

34.10

自引率

5.10%

发文量

期刊介绍： Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.