Impact of Caudate Lobe Resection on Overall Survival and Liver Disease-Free Survival in Colorectal Liver Metastases: A Pilot Study.

IF 1.4 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY
Melih Can Gül, Demirel Emin
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引用次数: 0

Abstract

Background/Aims: The objective of this study was to evaluate the impact of the resected caudate lobe on survival, particularly in the context of anatomical resection of liver metastases in colorectal cancers without metastases in the caudate lobe. Materials and Methods: Patient data were extracted from the dataset titled "Preoperative CT and Survival Data for Patients Undergoing Resection of Colorectal Liver Metastases (CRLM)." The analysis specifically concentrated on individuals who underwent complete cau- date lobe resection in the absence of radiological signs of metastasis within the caudate lobe itself. To discern the distinct impact of caudate lobe resection on patient outcomes, propensity score matching (PSM) was applied to control for variations across other relevant clinical parameters. Overall survival (OS) and liver disease-free survival (liver DFS) were calculated using the Kaplan-Meier method, while the log-rank test was used to compare survival outcomes between groups. Results: The analysis revealed that patients who underwent total caudate lobe resection exhibited significantly improved OS rates, both in the complete dataset and following PSM (P < .001, HR: 0.43, 95% CI: 0.26-0.72; P = .024, HR: 0.65, 95% CI: 0.59-0.79, respectively). Additionally, liver DFS outcomes were found to be superior in patients who had caudate lobe resection, in both the full dataset and the propensity-matched cohort (P = .014, HR = 0.46, 95% CI: 0.24-0.85; P = .026, HR = 0.5, 95% CI: 0.37-0.79, respectively). Conclusion: These findings suggest that incorporating total caudate lobe resection into the surgical management of CRLM may offer substantial benefits in terms of both OS and liver-specific disease-free survival.

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来源期刊
Turkish Journal of Gastroenterology
Turkish Journal of Gastroenterology 医学-胃肠肝病学
CiteScore
1.90
自引率
0.00%
发文量
127
审稿时长
6 months
期刊介绍: The Turkish Journal of Gastroenterology (Turk J Gastroenterol) is the double-blind peer-reviewed, open access, international publication organ of the Turkish Society of Gastroenterology. The journal is a bimonthly publication, published on January, March, May, July, September, November and its publication language is English. The Turkish Journal of Gastroenterology aims to publish international at the highest clinical and scientific level on original issues of gastroenterology and hepatology. The journal publishes original papers, review articles, case reports and letters to the editor on clinical and experimental gastroenterology and hepatology.
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