Diagnostic value of 99mTc-MDP single-photon emission computed tomography/computed tomography in medication-related osteonecrosis of the jaw: A single-center retrospective study of 39 patients

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-01-23 DOI:10.1016/j.jormas.2025.102262

Yubo Wei , Dongpo Li , Meng Wang , Guoliang Li , Fengzhi Liu , Xinfeng Liu , Shuangyi Wang , Lin Wang

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引用次数: 0

Abstract

Objective

The focus of this study was to assess the diagnostic effectiveness of ^99mTc-MDP single-photon emission computed tomography/computed tomography (SPECT/CT) in pinpointing medication-related osteonecrosis of the jaw (MRONJ).

Methods

We gathered a total of 39 patients who were suspected of having MRONJ and displayed radionuclide concentration in the jaws on whole-body bone scans. These patients were subjected to simultaneous SPECT/CT fusion imaging of the jaws during delayed imaging. A consistent team of nuclear medicine physicians and oral and maxillofacial surgeons carried out diagnostic evaluations using SPECT/CT image analysis and dental specialist examinations, and the diagnoses were documented.

Results

Based on the SPECT/CT image analysis and dental specialist examination outcomes, we calculated the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of ^99mTc-MDP SPECT/CT in diagnosing suspected MRONJ. Further, we enumerated the number and proportion of patients at each stage.

Conclusion

Our findings suggest that ^99mTc-MDP SPECT/CT demonstrates high diagnostic precision in patients suspected of MRONJ who display radionuclide concentration in the jaw on whole-body bone scans. Moreover, it proves beneficial in identifying the early stages of MRONJ.

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99mTc-MDP单光子发射计算机断层扫描/计算机断层扫描对颌骨药物相关性骨坏死的诊断价值：39例患者的单中心回顾性研究。

研究目的本研究的重点是评估99m锝-MDP单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）在确定药物相关性颌骨坏死（MRONJ）方面的诊断效果：我们共收集了39名疑似MRONJ患者，这些患者的全身骨扫描显示颌骨中存在放射性核素浓度。这些患者在延迟成像期间接受了颌骨同步 SPECT/CT 融合成像。由核医学医生和口腔颌面外科医生组成的医疗小组利用 SPECT/CT 图像分析和牙科专家检查进行诊断评估，并将诊断结果记录在案：根据 SPECT/CT 图像分析和牙科专家检查的结果，我们计算了 99mTc-MDP SPECT/CT 诊断疑似 MRONJ 的敏感性、特异性、准确性、阳性预测值和阴性预测值。此外，我们还统计了每个阶段的患者人数和比例：我们的研究结果表明，99m锝-MDP SPECT/CT 对全身骨扫描显示放射性核素在颌骨聚集的 MRONJ 疑似患者具有很高的诊断精确度。此外，它还有助于识别 MRONJ 的早期阶段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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