Neurovascular coupling dysfunction associated with inflammatory factors in sudden sensorineural hearing loss.

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience Pub Date : 2025-01-16 DOI:10.1016/j.neuroscience.2025.01.035

Chengyan Feng, Shuo Li, Chunhua Xing, Xiaomin Xu, Jin-Jing Xu, Wei Meng, Yu-Chen Chen, Zigang Che

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引用次数: 0

Abstract

Purpose: The neuropathologic mechanisms of sudden sensorineural hearing loss (SSNHL) are unknown. The aim of this study was to investigate the alterations of neurovascular coupling (NVC) in patients with SSNHL and its association with hematologic inflammatory factors.

Methods: The amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and degree centrality (DC) were calculated in 48 patients with SSNHL and 54 age-, gender-, and education-matched healthy control (HC), and also utilized the arterial spin labeling imaging (ASL) to calculate cerebral blood flow (CBF). Four indices of NVC (CBF-ALFF, CBF-fALFF, CBF-ReHo, and CBF-DC) in the whole brain gray matter as well as the NVC ratio were compared between two groups. In addition, correlation analyses were performed with inflammatory factors for the NVC indexes at the global level and regional level, respectively.

Results: The NVC at global level was lower in SSNHL group than in HC, except for CBF-ALFF. At the regional level, most of the brain regions with abnormal NVC in SSNHL patients involved auditory and sensorimotor language centers and limbic system compared to HC. In addition, both at the global and regional levels, NVC metrics were shown to correlate with partial inflammatory factors or hematologic parameters, including platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), systemic immunoinflammatory index (SII), blood platelet count (PLT), and lymphocyte count (Lym).

Conclusion: From the view of the NVC metrics, these findings provide new perspectives on the neuropathologic mechanisms and clinical treatment of SSNHL.

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突发性感音神经性听力损失与炎症因子相关的神经血管偶联功能障碍。

目的：突发性感音神经性听力损失（SSNHL）的神经病理机制尚不清楚。本研究旨在探讨SSNHL患者神经血管偶联（NVC）的改变及其与血液学炎症因子的关系。方法：计算48例SSNHL患者和54例年龄、性别和教育程度匹配的健康对照（HC）的低频波动幅度（ALFF）、低频波动分数幅度（fALFF）、区域均匀性（ReHo）和程度中心性（DC），并利用动脉自旋标记成像（ASL）计算脑血流量（CBF）。比较两组全脑灰质NVC的4项指标（CBF-ALFF、CBF-fALFF、CBF-ReHo、CBF-DC）及NVC比率。此外，对NVC指数在全球水平和区域水平上分别与炎症因子进行相关性分析。结果：除CBF-ALFF外，SSNHL组NVC整体水平均低于HC组。在区域水平上，与HC相比，SSNHL患者NVC异常的脑区多涉及听觉、感觉运动语言中心和边缘系统。此外，在全球和地区水平上，NVC指标被证明与部分炎症因子或血液学参数相关，包括血小板-淋巴细胞比率（PLR）、中性粒细胞-淋巴细胞比率（NLR）、全身免疫炎症指数（SII）、血小板计数（PLT）和淋巴细胞计数（Lym）。结论：从NVC指标的角度来看，这些发现为SSNHL的神经病理机制和临床治疗提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience 医学-神经科学

CiteScore

6.20

自引率

0.00%

发文量

394

审稿时长

52 days

期刊介绍： Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.