Yi Chai, Chengyu Chen, Xueru Yin, Xinru Wang, Wenyan Yu, Haochen Pan, Ruiying Qin, Xiyue Yang, Qiuzhen Wang
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引用次数: 0
Abstract
Background and objectives: Growing evidence has explored the effects of water-soluble vitamins supplementation on glycemic control and insulin resistance in diabetic patients; however, the results of previous meta-analyses are inconsistent. To address this, we conducted an umbrella review to synthesize the evidence on these effects.
Methods and study design: A systematic literature search in Web of science, PubMed, and Cochrane Database of Systematic Reviews was performed from 2012 to November 2022. he quality of the meta-analyses was assessed using AMSTAR-2 and GRADE.
Results: Fourteen systematic reviews and meta-analyses met the inclusion criteria, examining the effects of five water-soluble vitamins (B-1, B-3, biotin, B-9, and C) on glycemic control and insulin resistance. The findings suggest that vitamin C supplementation can improve glycemic control in type 2 diabetes, as indicated by reduced FBG and HbA1c, with more significant effects observed for durations longer than 30 days.
Conclusions: Insulin resistance is improved by folic acid supplementations. More well-designed individual randomized controlled trials are needed in the future, as well as meta-analysis of higher quality.
背景与目的：越来越多的证据表明，补充水溶性维生素对糖尿病患者血糖控制和胰岛素抵抗的影响；然而，先前的荟萃分析结果并不一致。为了解决这个问题，我们进行了一项综合综述，以综合这些影响的证据。方法和研究设计：系统检索Web of science、PubMed和Cochrane Database of systematic Reviews，检索时间为2012年至2022年11月。采用AMSTAR-2和GRADE评估meta分析的质量。结果：14项系统综述和荟萃分析符合纳入标准，检查了五种水溶性维生素（B-1、B-3、生物素、B-9和C）对血糖控制和胰岛素抵抗的影响。研究结果表明，补充维生素C可以改善2型糖尿病患者的血糖控制，如降低FBG和HbA1c所示，持续时间超过30天的效果更为显著。结论：补充叶酸可改善胰岛素抵抗。未来需要更多精心设计的个体随机对照试验，以及更高质量的荟萃分析。
期刊介绍：
The aims of the Asia Pacific Journal of Clinical Nutrition
(APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of
clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health
promotion and disease prevention. APJCN will publish
original research reports, reviews, short communications
and case reports. News, book reviews and other items will
also be included. The acceptance criteria for all papers are
the quality and originality of the research and its significance to our readership. Except where otherwise stated,
manuscripts are peer-reviewed by at least two anonymous
reviewers and the Editor. The Editorial Board reserves the
right to refuse any material for publication and advises
that authors should retain copies of submitted manuscripts
and correspondence as material cannot be returned. Final
acceptance or rejection rests with the Editorial Board
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