Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease.

IF 1.3 4区医学 Q4 NUTRITION & DIETETICS

Asia Pacific journal of clinical nutrition Pub Date : 2025-02-01 DOI:10.6133/apjcn.202502_34(1).0010

Hongli Dong, Nan Lu, Jie Wang, Ping Hu

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引用次数: 0

Abstract

Background and objectives: Mechanism studies have indicated that magnesium (Mg) and calcium (Ca) have important biological functions in glucose regulation, but epidemiological data on their associations with glycosylated hemoglobin (HbA1c) are sparse. We aimed to explore the associations of Mg and Ca with abnormal HbA1c, and examine the mediating effects of inflammation in coronary artery disease (CAD) Chinese adults.

Methods and study design: A hospital-based cross-sectional study of 11934 patients with CAD was conducted. Serum Mg and Ca concentrations were measured.

Results: In multivariable analyses, Mg and Mg/Ca ratio were inversely associated with abnormal HbA1c (Q4 vs Q1: ORMg: 0.61, 95% CIMg: 0.53, 0.71; ORMg/Ca ratio: 0.67, 95% CIMg/Ca ratio: 0.54, 0.84). However, null association of Ca with abnormal HbA1c was shown (Q4 vs Q1: OR: 1.15, 95% CI: 0.92, 1.44). Serum Mg and Mg/Ca ratio were inversely associated with abnormal fasting blood glucose (FBG). In contrast, serum Ca was positively associated with abnormal FBG. Path analysis indicated that there were no mediating effects of hypersensitivity C reactive protein (hsCRP) on Mg and Mg/Ca-abnormal HbA1c associations.

Conclusions: Our study suggested that serum Mg and Mg/Ca ratio were inversely associated with abnormal HbA1c in Chinese adults with CAD. The Mg-abnormal HbA1c relationship might not be mediated by hsCRP.

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成人冠状动脉疾病患者血清镁与异常HbA1c浓度呈负相关，而非钙。

背景与目的：机制研究表明，镁（Mg）和钙（Ca）在葡萄糖调节中具有重要的生物学功能，但关于它们与糖化血红蛋白（HbA1c）之间关系的流行病学数据很少。我们旨在探讨Mg和Ca与HbA1c异常的关系，并研究中国成人冠状动脉疾病（CAD）炎症的介导作用。方法和研究设计：对11934例冠心病患者进行了以医院为基础的横断面研究。测定血清Mg、Ca浓度。结果：在多变量分析中，Mg和Mg/Ca比值与异常HbA1c呈负相关(Q4 vs Q1: ORMg: 0.61, 95% CIMg: 0.53, 0.71；ORMg/Ca比值：0.67,95% CIMg/Ca比值：0.54,0.84)。然而，Ca与异常HbA1c无关联（Q4 vs Q1: OR: 1.15, 95% CI: 0.92, 1.44）。血清Mg和Mg/Ca比值与空腹血糖（FBG）异常呈负相关。相反，血清钙与FBG异常呈正相关。通径分析显示，超敏C反应蛋白（hsCRP）对Mg和Mg/ ca异常的HbA1c相关性没有介导作用。结论：我们的研究表明，中国成年冠心病患者血清Mg和Mg/Ca比值与HbA1c异常呈负相关。HbA1c与mg异常的关系可能不是由hsCRP介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia Pacific journal of clinical nutrition 医学-营养学

CiteScore

2.50

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board