Associations Between TCF7L2, PPARγ, and KCNJ11 Genotypes and Insulin Response to an Oral Glucose Tolerance Test: A Systematic Review

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2025-01-20 DOI:10.1002/mnfr.202400561

Carmen P. S. Blanken, Sandra Bayer, Sophie Buchner Carro, Hans Hauner, Christina Holzapfel

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引用次数: 0

Abstract

Scope: Insulin responses to standardized meals differ between individuals. This variability may in part be explained by genotype. This systematic review evaluates associations between genotype and insulin response to an oral glucose tolerance test (OGTT) in terms of insulin area under the curve (AUC). Methods and results: Three electronic databases (Web of Science, Embase, PubMed) were searched for studies investigating associations between insulin AUC after an OGTT and single nucleotide polymorphisms (SNPs) belonging to the transcription factor 7 like 2 (TCF7L2) gene, the peroxisome proliferator‐activated receptor gamma (PPARγ) gene, or the potassium inwardly rectifying channel subfamily J member 11 (KCNJ11) gene in persons without diabetes. A total of 5199 articles were identified, of which 38 were included. Among them were family‐based studies (9), twin studies (2), and studies with unrelated participants (27). Seventeen articles investigated TCF7L2 (7 SNPs), 14 investigated PPARγ (1 SNP), and 8 investigated KCNJ11 (5 SNPs). For all investigated SNPs, at least half of the reports indicated no statistically significant association with postprandial insulin AUC. Conclusion: No evidence was found for associations between TCF7L2, PPARγ, and KCNJ11 genotypes and insulin AUC after an OGTT. Future studies should investigate the effect of genetic risk scores on postprandial insulin.

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TCF7L2、PPARγ 和 KCNJ11 基因型与口服葡萄糖耐量试验的胰岛素反应之间的关系：系统综述

研究范围：胰岛素对标准化膳食的反应因人而异。这种变异性可以部分地用基因型来解释。本系统综述根据胰岛素曲线下面积（AUC）评估基因型与口服葡萄糖耐量试验（OGTT）胰岛素反应之间的关系。方法和结果：检索了三个电子数据库（Web of Science, Embase, PubMed），以调查OGTT后胰岛素AUC与转录因子7样2 （TCF7L2）基因、过氧化物酶体增殖物激活受体γ (PPARγ)基因或非糖尿病人钾内校正通道亚家族J成员11 （KCNJ11）基因的单核苷酸多态性（snp）之间的关系。共鉴定出5199篇文章，其中纳入38篇。其中包括基于家庭的研究（9项）、双胞胎研究（2项）和无关联参与者的研究（27项）。17篇研究了TCF7L2(7个SNP)， 14篇研究了PPARγ(1个SNP)， 8篇研究了KCNJ11（5个SNP）。对于所有被调查的snp，至少有一半的报告显示与餐后胰岛素AUC没有统计学意义的关联。结论：未发现TCF7L2、PPARγ和KCNJ11基因型与OGTT后胰岛素AUC相关的证据。未来的研究应探讨遗传风险评分对餐后胰岛素的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.