The emerging role of oxygen redox in pathological progression of disorders

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-02-01 DOI:10.1016/j.arr.2025.102660

Shuang-Yu Li , Xue-Yan Gong , Ferdinand Ndikuryayo , Wen-Chao Yang

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引用次数: 0

Abstract

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington disease, pose serious threats to human health, leading to substantial economic burdens on society and families. Despite extensive research, the underlying mechanisms driving these diseases remain incompletely understood, impeding effective diagnosis and treatment. In recent years, growing evidence has highlighted the crucial role of oxidative stress in the pathogenesis of various neurodegenerative diseases. However, there is still a lack of comprehensive reviews that systematically summarize the impact of mitochondrial oxidative stress on neurodegenerative diseases. This review aims to address this gap by summarizing the molecular mechanisms by which mitochondrial oxidative stress promotes the initiation and progression of neurodegenerative disorders. Furthermore, it discusses the potential of antioxidant-based therapeutic strategies for the treatment of these diseases. By shedding light on the role of mitochondrial oxidative stress in neurodegenerative diseases, this review not only serves as a valuable reference for further research on the disease mechanisms, but also offers novel perspectives for the treatment of these disorders.

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线粒体氧氧化还原在神经退行性疾病病理进展中的新作用。

神经退行性疾病，如阿尔茨海默病、帕金森病、亨廷顿病等，对人类健康构成严重威胁，给社会和家庭带来沉重的经济负担。尽管进行了广泛的研究，但导致这些疾病的潜在机制仍然不完全清楚，阻碍了有效的诊断和治疗。近年来，越来越多的证据强调了氧化应激在各种神经退行性疾病发病机制中的重要作用。然而，目前仍缺乏全面的综述系统地总结线粒体氧化应激对神经退行性疾病的影响。这篇综述旨在通过总结线粒体氧化应激促进神经退行性疾病的发生和进展的分子机制来解决这一空白。此外，它还讨论了治疗这些疾病的抗氧化剂为基础的治疗策略的潜力。本文综述了线粒体氧化应激在神经退行性疾病中的作用，不仅为进一步研究其发病机制提供了有价值的参考，也为神经退行性疾病的治疗提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.