Double-Helix Electrode Ion Funnel: A New Ion Funnel Design with an Extended Mass Range

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2025-01-13 DOI:10.1021/acs.analchem.4c04414

Bin Wu, Xingliang He, Xing Guo, Fulong Deng, Hongen Sun, Yi Pan, Yixiang Duan, Zhongjun Zhao

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Abstract

The development of an atmospheric pressure interface (API) with a high ion transfer efficiency and wide mass range is advantageous for the performance improvement of mass spectrometry (MS) instruments. In this work, a novel ion guide, namely, the double-helix electrode ion funnel (DHE-IF), has been developed to enhance the ion transmission over a wide mass range in the rough vacuum region. The DHE-IF consists of two funnel-shaped helix electrodes. There are almost no potential “traps” along the central axis of DHE-IF due to the continuous double-helix electrode structure compared to the stacked ring ion funnel. The electrode design of the DHE-IF assembly was guided by ion trajectory simulations. After being fabricated, DHE-IF was integrated into an ESI-TOF-MS platform for tests. A conventional stacked ring ion funnel (IF) was also tested for comparison. The experimental results showed that DHE-IF extended the transmission window of the IF and improved the efficiency of the simultaneous transferring of low and medium m/z ions. In addition, the intensities of caffeine ions (m/z = 195) and reserpine ions (m/z = 609) were enhanced by more than 50% and 10%, respectively. These values were compared with the results obtained by the IF. The DHE-IF is expected to be widely used as an ion import device in MS instruments, which is due to its improved performance and advantages in, e.g., integration and power supply design.

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.