Pharmacological treatment for substance use disorder: A systematic review

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors Pub Date : 2025-01-02 DOI:10.1016/j.addbeh.2024.108242

Joaquín Mateu-Mollá , Bartolomé Pérez-Gálvez , Víctor José Villanueva-Blasco

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引用次数: 0

Abstract

Introduction

There is strong evidence of the substance dependence has a negative impact on key dimensions of health. The scientific evidence suggests that pharmacological treatment could play a fundamental role in its clinical management. Objective: The aim of this systematic review is to explore the existing pharmacological options for the treatment of substance use disorders. Methods: Following PRISMA recommendations, a review of recent scientific literature was conducted using three sources of information: Pubmed /Medline, Web of Science, and Scopus. Only randomized controlled trials published in the last five years, in both English and Spanish, and subjected to peer review were selected. The quality of the methodology used was defined through the application of the PEDro scale for quantitative studies. It was registered in the PROSPERO database. Results: After filtering through the respective advanced search engines, a total of 49 articles suitable for qualitative analysis were retrieved. Literature related to pharmacotherapy for alcohol use, as well as for cocaine, tobacco, cannabis, and opioid dependence, was identified among them. Conclusions: There is a wide variety of drugs that can be used for the clinical management of dependence on these substances. Reflections are offered on the evidence of their effectiveness and the methodological rigor of the literature.

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药物使用障碍的药物治疗：系统综述。

导言：有强有力的证据表明，物质依赖对健康的关键方面产生负面影响。科学证据表明，药物治疗可在其临床管理中发挥基础性作用。目的：本系统综述的目的是探讨药物使用障碍治疗的现有药理学选择。方法：根据PRISMA的建议，使用三个信息来源：Pubmed /Medline、Web of Science和Scopus对最近的科学文献进行了回顾。只选择了最近5年发表的随机对照试验，用英语和西班牙语，并经过同行评审。通过应用PEDro量表进行定量研究来确定所使用方法的质量。在普洛斯彼罗数据库中登记过。结果：经过各自高级搜索引擎的筛选，共检索到49篇适合定性分析的文章。其中包括与酒精使用药物治疗以及可卡因、烟草、大麻和阿片类药物依赖相关的文献。结论：有多种药物可用于临床管理对这些物质的依赖。反思提供的证据，他们的有效性和方法的严谨性的文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.