Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-02-01 DOI:10.1016/j.brainresbull.2025.111204

Fengxia Yu , Dong Liu , Xia Ma , Yawen Liu , Linkun Cai , Erwei Zhao , Zixu Huang , Zhe Zhang , Tingting Zhang , PengGang Qiao , Wei Zheng , Chunyan Guo , Linxue Qian , Pengling Ren , Zhenchang Wang

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引用次数: 0

Abstract

Purpose

Dobutamine, a sympathomimetic agent, is widely used clinically, influencing cardiac output, heart rate (HR), and blood pressure (BP), which may impact cerebral blood flow (CBF), critical for brain metabolism. However, the effects of dobutamine on CBF and internal carotid artery (ICA) blood flow remain unclear, with contradictory reported in both clinical and animal studies. It is necessary to investigate the effects of dobutamine on cervical and cerebral hemodynamics. This study aimed to evaluate the effects of dobutamine infusion on ICA blood flow and CBF, explore their relationship, and identify factors influencing CBF to facilitate timely monitoring in clinical practice.

Methods

Forty-eight healthy volunteers underwent physiological assessment, ICA ultrasound, and brain magnetic resonance imaging (MRI) data before and after the administration of dobutamine. Paired t and Wilcoxon signed-rank tests were used to analyze changes, while logistic regression explored associations between hemodynamic factors and CBF.

Results

Dobutamine infusion significantly increased HR, respiration rate, systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure, while blood oxygen remained stable. Compared with those in the resting state, the peak systolic velocity (Vs), resistance index, pulsatility index, and systolic/diastolic ratio (S/D) increased, whereas end-diastolic velocity (Vd) decreased. ICA diameter and mean velocity showed no significant changes. CBF significantly decreased in the anterior and middle cerebral arteries. Logistic regression identified SBP, DBP, and S/D difference as key factors associated with CBF reduction.

Conclusions

Dobutamine altered ICA hemodynamics and reduced CBF in anterior and middle cerebral arteries. Real-time ICA ultrasound monitoring provides valuable guidance during clinical use.

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多巴酚丁胺诱导的健康成人颈内动脉血流和脑血流的改变。

目的：多巴酚丁胺是一种临床广泛使用的拟交感神经药物，可影响心输出量、心率（HR）和血压（BP），从而影响脑血流量（CBF），对脑代谢至关重要。然而，多巴酚丁胺对CBF和颈内动脉（ICA）血流的影响尚不清楚，临床和动物研究中都有相互矛盾的报道。有必要研究多巴酚丁胺对颈、脑血流动力学的影响。本研究旨在评价多巴酚丁胺输注对ICA血流和CBF的影响，探讨两者之间的关系，识别影响CBF的因素，以便在临床实践中及时监测。方法：48名健康志愿者在给予多巴酚丁胺前后进行了生理评估、ICA超声和脑磁共振成像（MRI）数据。使用配对t和Wilcoxon符号秩检验分析变化，而逻辑回归探讨血流动力学因素与CBF之间的关系。结果：多巴酚丁胺输注显著提高心率、呼吸频率、收缩压、舒张压和平均动脉压，血氧保持稳定。与静息状态相比，收缩峰值速度（Vs）、阻力指数、搏动指数、收缩/舒张比升高，舒张末期速度（Vd）降低。ICA直径和平均速度没有变化。脑血流在大脑前动脉和中动脉明显减少。Logistic回归发现收缩压、舒张压和S/D差异是与CBF降低相关的关键因素。结论：多巴酚丁胺改变了大脑前动脉和大脑中动脉的ICA血流动力学并降低了CBF。实时ICA超声监测为临床使用提供了有价值的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.