Pre- and Post-COVID-19 Antibiotic Consumption and Stewardship Program in a Southern Italian Hospital.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

Antibiotics-Basel Pub Date : 2024-11-24 DOI:10.3390/antibiotics13121128

Maria Costantino, Valentina Giudice, Federica Campana, Alessandra Anna Iannelli, Pasqualina Scala, Walter Longanella, Francesco Marongiu, Emilia Anna Vozzella, Maria Giovanna Elberti, Maria Alfieri, Giovanni Boccia, Valeria Conti, Francesco De Caro, Amelia Filippelli

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引用次数: 0

Abstract

Background/objectives: Antibiotic resistance is a growing global threat that significantly impacts public health and healthcare costs. The Italian National Action Plan on Antimicrobial Resistance (PNCAR) was introduced in 2017 to address this issue by improving antibiotic stewardship. This study aimed to evaluate the effectiveness of the PNCAR in enhancing antibiotic management practices in a hospital in southern Italy before and after its implementation.

Methods: We conducted an observational monocentric study to analyze antibiotic consumption in a hospital setting before and after the COVID-19 pandemic (2019 and 2023) and to examine prescription appropriateness and the types of used antibiotics.

Results: After PNCAR introduction, we recorded a significant increase in antibiotic prescription appropriateness and in Access antibiotic and targeted therapy usage, while Reserve antibiotics were prescribed in ~10% of the cases, with an increasing trend in 2023.

Conclusions: Our study supports the importance of targeted stewardship initiatives, including continuous monitoring and education, to sustain antibiotic prescription appropriateness and to reduce antimicrobial resistance.

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意大利南部一家医院covid -19前后抗生素消费和管理项目

背景/目的：抗生素耐药性是一个日益严重的全球威胁，严重影响公共卫生和医疗保健费用。意大利于2017年推出了《抗微生物药物耐药性国家行动计划》（PNCAR），旨在通过改善抗生素管理来解决这一问题。本研究旨在评估PNCAR在实施前后在意大利南部一家医院加强抗生素管理实践方面的有效性。方法：我们开展了一项单中心观察性研究，分析2019年和2023年COVID-19大流行前后某医院的抗生素使用情况，并检查处方的适宜性和使用的抗生素类型。结果：引入PNCAR后，我们的抗生素处方适宜性、可及性抗生素和靶向治疗的使用显著增加，而储备抗生素的使用比例约为10%，并在2023年呈上升趋势。结论：我们的研究支持有针对性的管理举措的重要性，包括持续监测和教育，以维持抗生素处方的适当性和减少抗菌素耐药性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

7.30

自引率

14.60%

发文量

1547

审稿时长

11 weeks

期刊介绍： Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.