Identification of quantitative trait loci and candidate genes associated with growth curve parameters in chinese wenshang barred chickens

IF 3.8 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Poultry Science Pub Date : 2025-02-01 DOI:10.1016/j.psj.2025.104767

Yan Zhou , Jie Liu , Qiuxia Lei , Haixia Han , Wei Liu , Dapeng Li , Yan Sun , Dan Hao , Fuwei Li , Dingguo Cao , Jie Wang

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引用次数: 0

Abstract

The growth curve is a vital instrument for assessing and forecasting weight and developmental shifts in livestock and poultry, which reflects the changes of bodyweight traits with time and plays a key role in guiding breeding and production approaches. This study performed a genome-wide association study (GWAS) for growth curve parameters generated by nonlinear models which fit original weight-age records, to discover the SNPs and candidate genes correlated with growth traits. Data from 362 Chinese Wenshang Barred Chickens weighed at the age of 0, 2, 4, 6, 8, 10, 12, 14, 16, and 18 weeks were used to fit the Gompertz, Logistic, and von Bertalanffy growth models. The Gompertz model showed the highest coefficient of determination (R² = 0.974). The mature body weight (A), time scale (b), and maturity rate (k) were treated as phenotypes for single-trait GWAS. The GWAS identified 44, 103, and 5 significant single nucleotide polymorphisms (SNPs) associated with A, b, and K, respectively. Among them, several candidate genes, including LDB2, TOB2, RCBTB1, KPNA3, SLIT2, LCORL, LAP3, and TPRA1, were previously reported to be associated with growth and development. Two lead SNPs (4:76022389, 4:76070237) on the LDB2 gene were significantly associated with the growth curve. Further research of these candidate genes could help explore the full genetic architecture underlying growth and development traits in poultry.

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文上棒鸡生长曲线参数相关数量性状位点及候选基因的鉴定。

生长曲线是评估和预测畜禽体重和发育变化的重要工具，它反映了畜禽体重性状随时间的变化，对指导育种和生产方法具有重要作用。本研究对拟合原始体重年龄记录的非线性模型生成的生长曲线参数进行了全基因组关联研究（GWAS），以发现与生长性状相关的snp和候选基因。选用362只0、2、4、6、8、10、12、14、16和18周龄中国文上白斑鸡的数据，拟合Gompertz、Logistic和von Bertalanffy生长模型。Gompertz模型的决定系数最高（R2 = 0.974）。成熟体重(A)、时间尺度(b)和成熟率(k)作为单性状GWAS的表型。GWAS分别鉴定出44、103和5个与A、b和K相关的显著单核苷酸多态性（snp）。其中，几个候选基因，包括LDB2、TOB2、RCBTB1、KPNA3、SLIT2、LCORL、LAP3和TPRA1，先前被报道与生长发育相关。LDB2基因上的两个先导snp（4:76022389, 4:76070237）与生长曲线显著相关。对这些候选基因的进一步研究有助于探索家禽生长发育性状的完整遗传结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Poultry Science 农林科学-奶制品与动物科学

CiteScore

7.60

自引率

15.90%

发文量

审稿时长

94 days

期刊介绍： First self-published in 1921, Poultry Science is an internationally renowned monthly journal, known as the authoritative source for a broad range of poultry information and high-caliber research. The journal plays a pivotal role in the dissemination of preeminent poultry-related knowledge across all disciplines. As of January 2020, Poultry Science will become an Open Access journal with no subscription charges, meaning authors who publish here can make their research immediately, permanently, and freely accessible worldwide while retaining copyright to their work. Papers submitted for publication after October 1, 2019 will be published as Open Access papers. An international journal, Poultry Science publishes original papers, research notes, symposium papers, and reviews of basic science as applied to poultry. This authoritative source of poultry information is consistently ranked by ISI Impact Factor as one of the top 10 agriculture, dairy and animal science journals to deliver high-caliber research. Currently it is the highest-ranked (by Impact Factor and Eigenfactor) journal dedicated to publishing poultry research. Subject areas include breeding, genetics, education, production, management, environment, health, behavior, welfare, immunology, molecular biology, metabolism, nutrition, physiology, reproduction, processing, and products.