Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications

IF 33.6 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Progress in Materials Science Pub Date : 2025-01-09 DOI:10.1016/j.pmatsci.2025.101428

Sravan Baddi, Auphedeous Y. Dang-i, Fengli Gao, Xiaxin Qiu, Chuanliang Feng

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Abstract

Co-assembly is a key phenomenon in life, playing a significant role in various biological processes. In particular, supramolecular composite hydrogels (SMCHs) form through the incorporation of diverse functionalities, such as small molecules, polymers, peptides, proteins, nanoparticles, metal ions, and carbon nanomaterials via a co-assembly approach. This approach imparts tunable properties to the resulting hydrogels, including mechanical strength, elasticity, porosity, and responsiveness to external stimuli, thereby enhancing their overall performance compared to their individual constituents. The versatile advantages of SMCHs extend their applications to fields such as targeted drug delivery, tissue engineering, and regenerative medicine. This review offers a comprehensive overview of the key design principles and the physical strategies used to transform supramolecular hydrogels (SMHs) into SMCHs. Furthermore, it highlights recent advances in their biomedical applications, including 3D cell culture, antibacterial properties, anti-inflammatory effects, wound healing, cancer therapy, treatment of ocular infections, dental tissue repair, gastric tissue repair, cardiac tissue regeneration, bone regeneration, and disk repair, is systematically highlighted. We aim to provide innovative perspectives and critical insights into the design and development of SMCHs while addressing their current limitations and challenges, with the goal of advancing their practical applications

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来源期刊

Progress in Materials Science 工程技术-材料科学：综合

CiteScore

59.60

自引率

0.80%

发文量

101

审稿时长

11.4 months

期刊介绍： Progress in Materials Science is a journal that publishes authoritative and critical reviews of recent advances in the science of materials. The focus of the journal is on the fundamental aspects of materials science, particularly those concerning microstructure and nanostructure and their relationship to properties. Emphasis is also placed on the thermodynamics, kinetics, mechanisms, and modeling of processes within materials, as well as the understanding of material properties in engineering and other applications. The journal welcomes reviews from authors who are active leaders in the field of materials science and have a strong scientific track record. Materials of interest include metallic, ceramic, polymeric, biological, medical, and composite materials in all forms. Manuscripts submitted to Progress in Materials Science are generally longer than those found in other research journals. While the focus is on invited reviews, interested authors may submit a proposal for consideration. Non-invited manuscripts are required to be preceded by the submission of a proposal. Authors publishing in Progress in Materials Science have the option to publish their research via subscription or open access. Open access publication requires the author or research funder to meet a publication fee (APC). Abstracting and indexing services for Progress in Materials Science include Current Contents, Science Citation Index Expanded, Materials Science Citation Index, Chemical Abstracts, Engineering Index, INSPEC, and Scopus.