A Straightforward Synthesis of Pinocembrin.

Abstract

A simple synthetic method for pinocembrin from cinnamic acid and 1,3,5-trihydroxybenzene was provided. This method can be performed in one-pot two steps reaction using inexpensive chemical reagents, whereas conventional methods need multiple steps from somewhat expensive starting reagents. The experimental procedure is facilitated, that is, to a DMF solution of cinnamoyl chloride generated in situ, a solution of 1,3,5-trihydroxybenzene and AlCl ₃ in DCE/PhNO ₂ was added, and the resultant mixture was heated to afford pinocembrin. This method does not require protection of phenolic hydroxy groups.