Targeted microbiota dysbiosis repair: An important approach to health management after spinal cord injury

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-02-01 DOI:10.1016/j.arr.2024.102648

Cheng Ju , Renfeng Liu , Yanming Ma , Hui Dong , Ruiqing Xu , Huimin Hu , Dingjun Hao

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引用次数: 0

Abstract

Current research primarily focuses on the pathological mechanisms of spinal cord injury (SCI), seeking to promote spinal cord repair and restore motorial and sensory functions by elucidating mechanisms of cell death or axonal regeneration. However, SCI is almost irreversible, and patients often struggle to regain mobility or self-care abilities after injuries. Consequently, there has been significant interest in modulating systemic symptoms following SCI to improve patients' quality of life. Neuron axonal disconnection and substantial apoptotic events following SCI result in signal transmission loss, profoundly impacting various organ and systems, including the gastrointestinal tract. Dysbiosis can lead to severe bowel dysfunction in patients, substantially lowering their quality of life and significantly reducing life expectancy of them. Therefore, researches focusing on the restoration of the gut microbiota hold promise for potential therapeutic strategies aimed at rehabilitation after SCI. In this paper, we explore the regulatory roles that dietary fiber, short-chain fatty acids (SCFAs), probiotics, and microbiota transplantation play in patients with SCI, summarize the potential mechanisms of post-SCI dysbiosis, and discuss possible strategies to enhance long-term survival of SCI patients. We aim to provide potential insights for future research aimed at ameliorating dysbiosis in SCI patients.

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靶向微生物群失调修复：脊髓损伤后健康管理的重要途径。

目前的研究主要集中在脊髓损伤（SCI）的病理机制，寻求通过阐明细胞死亡或轴突再生的机制来促进脊髓修复和恢复运动和感觉功能。然而，脊髓损伤几乎是不可逆的，患者在受伤后往往难以恢复活动能力或自我照顾能力。因此，人们对调节脊髓损伤后的全身症状以改善患者的生活质量非常感兴趣。脊髓损伤后神经元轴突断开和大量凋亡事件导致信号传递丧失，深刻影响包括胃肠道在内的多个器官和系统。生态失调可导致患者严重的肠道功能障碍，大大降低患者的生活质量，显著缩短患者的预期寿命。因此，专注于肠道微生物群恢复的研究有望为脊髓损伤后的康复提供潜在的治疗策略。本文探讨了膳食纤维、短链脂肪酸（SCFAs）、益生菌和微生物群移植在脊髓损伤患者中的调节作用，总结了脊髓损伤后生态失调的潜在机制，并探讨了提高脊髓损伤患者长期生存率的可能策略。我们的目标是为未来的研究提供潜在的见解，旨在改善脊髓损伤患者的生态失调。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.