Distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples.

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2024-12-21 DOI:10.1016/j.idnow.2024.105019

Kaisar Rahman, Babafela Awosile

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Abstract

Background: This study aimed to explore the distribution of beta-lactamase genes in Enterobacteriaceae from human clinical samples.

Methods: We analyzed data from 83 countries through the Antimicrobial Testing Leadership and Surveillance program, spanning 2004 to 2021. We calculated the proportion of each β-lactamase gene across nine bacterial species and generated a heatmap for β-lactamase genes with a frequency of ≥ 1 % in at least one species.

Results: A total of 359 β-lactamase genes were identified, with the highest proportion found in Klebsiella spp. (61.84 %, n = 222), followed by Escherichiacoli (47.63 %, n = 171), and Proteus spp. (20.61 %, n = 74). The ESBL gene bla_CTX-M-15 was most prevalent in Klebsiella spp. (62.39 %) and E.coli (53.16 %). The carbapenemase genes bla_NDM-1, bla_OXA-48, and bla_KPC-2 were notably higher in Providencia spp. (59.47 %), Raoultella spp. (45.45 %), and Serratia spp. (25.24 %), respectively.

Conclusion: Further surveillance and research are needed to investigate the diversity of β-lactamase genes across One Health interfaces.

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