Yi Sun, Lifeng Qian, Biwen Wu, Hongru Sun, Jiang Hu, Sangsheng Zhu, Jiaye Cai, Huaying Cai, Ximiao Jiang, Yu Sun
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引用次数: 0
Abstract
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is recognized as a prodromal stage of neuro-degenerative disease. While brain network analysis is a well-documented approach for characterizing disease-related dysfunctions, the specific patterns in iRBD, particularly those related to hemispheric aberrations remain largely unexplored. To address this gap, this study investigated the topological abnormalities of multi-band EEG networks in patients with iRBD. Specifically, eyes-open resting-state EEG signals were collected from 30 iRBD patients and 30 matched health control (HC) participants. Graph theoretical analysis was then employed to explore network properties at the whole-brain and the hemispheric level. At the whole-brain level, we found aberrant increased local and global efficiency along with a distinct pattern of increased frontal and decreased parietal nodal efficiency in the alpha band of iRBD patients. At the hemispheric level, iRBD networks displayed more efficient topological properties in the left hemisphere. Additionally, significant hemispheric asymmetry was observed in the alpha-band iRBD network compared to that of HC. In sum, these findings provide novel insights into the disrupted network reorganization in iRBD and suggest aberrant hemispheric asymmetry as a potential neural biomarker for early diagnosis and monitoring of the disease.
期刊介绍:
The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.