The mammalian locomotor CPG: Revealing the contents of the black box.

IF 2.1 3区 医学 Q3 NEUROSCIENCES
Simon Gosgnach
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Abstract

It has long been known that a neural circuit situated in the spinal cord of mammals is independently capable of generating and modulating locomotor movements. Following its initial discovery over a century ago, a great deal of research has been focused on characterizing this neural circuit to determine how it is able to elicit movement. For much of the 20th century difficulty identifying individual component interneurons that comprised this neural circuit resulted in it being considered a powerful but mysterious "black box". In this article we will review the development of a number of innovative experimental approaches that have brought us to the current state of research in the field, where we are able to identify populations that comprise this neural circuit, pinpoint their specific function, and image their activity in real time during a locomotor task.

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来源期刊
Journal of neurophysiology
Journal of neurophysiology 医学-神经科学
CiteScore
4.80
自引率
8.00%
发文量
255
审稿时长
2-3 weeks
期刊介绍: The Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems electrophysiology, imaging and mapping techniques, and behavioral analysis. Experimental preparations may be invertebrate or vertebrate species, including humans. Theoretical studies are acceptable if they are tied closely to the interpretation of experimental data and elucidate principles of broad interest.
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