{"title":"Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study.","authors":"Yunxia Feng, Yuan Li, Shuo Chen, Na Hu, Dan Liao","doi":"10.3389/fnut.2024.1469844","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.</p><p><strong>Methods: </strong>This was a population-based cohort study. CKD participants from the National Health and Nutrition Examination Survey (NHANES) database were included for analysis. The primary outcome was all-cause mortality. Person correlation analysis and Cox regression models were used to assess the relation between serum VA levels and all-cause mortality among individuals with CKD.</p><p><strong>Results: </strong>There were 689 participants included in this study. The serum VA level was 2.45 ± 1.06 μmol/L. The overall mortality was 43.69%. The participants in the nonsurvival group had higher serum VA levels than those in the survival group (2.18 ± 0.82 vs. 2.78 ± 1.24 μmol/L, <i>p</i> < 0.01). Serum VA concentrations were positively correlated with serum creatinine levels (r = 0.56, <i>p</i> < 0.01) and urea nitrogen (r = 0.58, <i>p</i> < 0.01) but negatively correlated with eGFR (r = -0.56, <i>p</i> < 0.01). The serum VA level was independently related to all-cause mortality (hazard ratio (HR) = 1.15, [95% CI: 1.01-1.31], <i>p</i> = 0.03). The Kaplan-Meier survival analysis suggested that the survival probability was lower in participants with serum VA levels exceeding 2.09 μmol/L than in participants with serum VA levels below 2.09 μmol/L (<i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>A high serum VA was independently related to all-cause mortality in CKD patients. VA requirements for patients with CKD is worth studies in the future.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1469844"},"PeriodicalIF":4.0000,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652194/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2024.1469844","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: The association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.
Methods: This was a population-based cohort study. CKD participants from the National Health and Nutrition Examination Survey (NHANES) database were included for analysis. The primary outcome was all-cause mortality. Person correlation analysis and Cox regression models were used to assess the relation between serum VA levels and all-cause mortality among individuals with CKD.
Results: There were 689 participants included in this study. The serum VA level was 2.45 ± 1.06 μmol/L. The overall mortality was 43.69%. The participants in the nonsurvival group had higher serum VA levels than those in the survival group (2.18 ± 0.82 vs. 2.78 ± 1.24 μmol/L, p < 0.01). Serum VA concentrations were positively correlated with serum creatinine levels (r = 0.56, p < 0.01) and urea nitrogen (r = 0.58, p < 0.01) but negatively correlated with eGFR (r = -0.56, p < 0.01). The serum VA level was independently related to all-cause mortality (hazard ratio (HR) = 1.15, [95% CI: 1.01-1.31], p = 0.03). The Kaplan-Meier survival analysis suggested that the survival probability was lower in participants with serum VA levels exceeding 2.09 μmol/L than in participants with serum VA levels below 2.09 μmol/L (p < 0.0001).
Conclusion: A high serum VA was independently related to all-cause mortality in CKD patients. VA requirements for patients with CKD is worth studies in the future.
期刊介绍:
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.