Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2024-12-04 eCollection Date: 2024-01-01 DOI:10.3389/fnut.2024.1469844

Yunxia Feng, Yuan Li, Shuo Chen, Na Hu, Dan Liao

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Abstract

Introduction: The association between serum vitamin A (VA) levels and outcomes in chronic kidney disease (CKD) patients remains unclear.

Methods: This was a population-based cohort study. CKD participants from the National Health and Nutrition Examination Survey (NHANES) database were included for analysis. The primary outcome was all-cause mortality. Person correlation analysis and Cox regression models were used to assess the relation between serum VA levels and all-cause mortality among individuals with CKD.

Results: There were 689 participants included in this study. The serum VA level was 2.45 ± 1.06 μmol/L. The overall mortality was 43.69%. The participants in the nonsurvival group had higher serum VA levels than those in the survival group (2.18 ± 0.82 vs. 2.78 ± 1.24 μmol/L, p < 0.01). Serum VA concentrations were positively correlated with serum creatinine levels (r = 0.56, p < 0.01) and urea nitrogen (r = 0.58, p < 0.01) but negatively correlated with eGFR (r = -0.56, p < 0.01). The serum VA level was independently related to all-cause mortality (hazard ratio (HR) = 1.15, [95% CI: 1.01-1.31], p = 0.03). The Kaplan-Meier survival analysis suggested that the survival probability was lower in participants with serum VA levels exceeding 2.09 μmol/L than in participants with serum VA levels below 2.09 μmol/L (p < 0.0001).

Conclusion: A high serum VA was independently related to all-cause mortality in CKD patients. VA requirements for patients with CKD is worth studies in the future.

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维生素A与慢性肾病患者的全因死亡率相关：一项基于人群的队列研究

慢性肾脏疾病（CKD）患者血清维生素A （VA）水平与预后之间的关系尚不清楚。方法：这是一项基于人群的队列研究。来自国家健康和营养检查调查（NHANES）数据库的CKD参与者被纳入分析。主要结局为全因死亡率。采用个体相关分析和Cox回归模型评估CKD患者血清VA水平与全因死亡率之间的关系。结果：本研究共纳入689名受试者。血清VA水平为2.45 ± 1.06 μmol/L。总死亡率为43.69%。的参与者nonsurvival组血清VA水平高于生存组(2.18 ± 0.82 vs 2.78 ±1.24  μmol / L p  p   = 0.03页)。Kaplan-Meier生存分析显示，血清VA水平超过2.09 μmol/L的患者的生存概率低于血清VA水平低于2.09 μmol/L的患者（p ）。结论：血清VA水平高与CKD患者的全因死亡率独立相关。CKD患者的VA需求值得未来研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.