Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study.

IF 7.2 2区医学 Q1 PSYCHIATRY

European Psychiatry Pub Date : 2024-12-18 DOI:10.1192/j.eurpsy.2024.1809

Chuyu Pan, Bolun Cheng, Shiqiang Cheng, Li Liu, Xuena Yang, Peilin Meng, Xin Qi, Na Zhang, Xiaoyue Qin, Dan He, Wenming Wei, Jingni Hui, Yan Wen, Yumeng Jia, Huan Liu, Feng Zhang

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引用次数: 0

Abstract

Background: Despite growing awareness of the mental health damage caused by air pollution, the epidemiologic evidence on impact of air pollutants on major mental disorders (MDs) remains limited. We aim to explore the impact of various air pollutants on the risk of major MD.

Methods: This prospective study analyzed data from 170 369 participants without depression, anxiety, bipolar disorder, and schizophrenia at baseline. The concentrations of particulate matter with aerodynamic diameter ≤ 2.5 μm (PM_2.5), particulate matter with aerodynamic diameter > 2.5 μm, and ≤ 10 μm (PM_2.5-10), nitrogen dioxide (NO₂), and nitric oxide (NO) were estimated using land-use regression models. The association between air pollutants and incident MD was investigated by Cox proportional hazard model.

Results: During a median follow-up of 10.6 years, 9 004 participants developed MD. Exposure to air pollution in the highest quartile significantly increased the risk of MD compared with the lowest quartile: PM_2.5 (hazard ratio [HR]: 1.16, 95% CI: 1.09-1.23), NO₂ (HR: 1.12, 95% CI: 1.05-1.19), and NO (HR: 1.10, 95% CI: 1.03-1.17). Subgroup analysis showed that participants with lower income were more likely to experience MD when exposed to air pollution. We also observed joint effects of socioeconomic status or genetic risk with air pollution on the MD risk. For instance, the HR of individuals with the highest genetic risk and highest quartiles of PM_2.5 was 1.63 (95% CI: 1.46-1.81) compared to those with the lowest genetic risk and lowest quartiles of PM_2.5.

Conclusions: Our findings highlight the importance of air pollution control in alleviating the burden of MD.

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长期环境空气污染与重大精神障碍风险：一项前瞻性队列研究。

背景：尽管人们越来越认识到空气污染对精神健康造成的损害，但关于空气污染物对主要精神障碍（MDs）影响的流行病学证据仍然有限。我们的目的是探讨各种空气污染物对主要医学风险的影响。方法：这项前瞻性研究分析了170 369名无抑郁、焦虑、双相情感障碍和精神分裂症的参与者的基线数据。利用土地利用回归模型估算空气动力直径≤2.5 μm颗粒物（PM2.5）、空气动力直径> 2.5 μm颗粒物和≤10 μm颗粒物（PM2.5-10）、二氧化氮（NO2）和一氧化氮（NO）的浓度。采用Cox比例风险模型研究了大气污染物与事故MD之间的关系。结果：在10.6年的中位随访期间，有9,004名参与者患上了MD。与最低四分位数的空气污染相比，暴露在最高四分位数的空气污染中显著增加了患MD的风险：PM2.5（风险比[HR]: 1.16, 95% CI: 1.09-1.23）， NO2 （HR: 1.12, 95% CI: 1.05-1.19）和NO （HR: 1.10, 95% CI: 1.03-1.17）。亚组分析显示，收入较低的参与者在暴露于空气污染时更有可能患上MD。我们还观察到社会经济地位或遗传风险与空气污染对MD风险的共同影响。例如，与遗传风险最低和PM2.5最低四分位数的个体相比，遗传风险最高和PM2.5最高四分位数的个体的HR为1.63 （95% CI: 1.46-1.81）。结论：我们的研究结果强调了空气污染控制对减轻MD负担的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Psychiatry 医学-精神病学

CiteScore

8.50

自引率

3.80%

发文量

2338

审稿时长

4.5 weeks

期刊介绍： European Psychiatry, the official journal of the European Psychiatric Association, is dedicated to sharing cutting-edge research, policy updates, and fostering dialogue among clinicians, researchers, and patient advocates in the fields of psychiatry, mental health, behavioral science, and neuroscience. This peer-reviewed, Open Access journal strives to publish the latest advancements across various mental health issues, including diagnostic and treatment breakthroughs, as well as advancements in understanding the biological foundations of mental, behavioral, and cognitive functions in both clinical and general population studies.