Manipulating Near-Infrared Absorption via Engineering Anisotropic Plasmonic Spiky Au Nanocubes for the Highly Efficient Dual-Response Immune Detection of T-2 Toxin

IF 6.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL
Rui Shu, Kexin Wang, Meilin Wang, Sijie Liu, Jiayi Zhang, Ibrahim A. Darwish, Jianlong Wang, Daohong Zhang
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Abstract

Integrating specific immune recognition, a desirable extinction coefficient, and conspicuous photothermal conversion ability into a single-immune probe to enhance the analysis performance represents an appealing yet significantly challenging task. Herein, by delicately manipulating the geometry of plasmonic nanoparticles from spherical to spiky, precise engineering approach-based spiky Au nanocubes (S-AuNCs) are employed to address this challenge, which fully exploits the plasmon resonance absorption-induced photothermal effect. The finite difference time domain (FDTD) method was employed to computationally simulate the electromagnetic and thermal fields while assessing the feasibility of regulating plasmon resonance for enhanced photothermal absorption. The optimized noble photothermal agent simultaneously exhibits acceptable near-infrared absorption (NIR), a significantly increased 808 nm extinction coefficient (145 times higher than that of AuNPs), favorable antibody coupling ability, and desirable photothermal conversion behavior. Consequently, the satisfactory performance of the S-AuNCs-guided colorimetric and photothermal lateral flow immunoassay (CPLFIA) is demonstrated for the sensitive detection of T-2 toxin. In comparison to spherical AuNPs (35.2 pg/mL), the dual-mode detection sensitivity was enhanced by 1.862-fold and 5.18-fold, respectively, achieving limits of detection at 18.9 pg/mL (colorimetric mode) and 6.8 pg/mL (photothermal mode). Therefore, S-AuNCs-guided CPLFIA holds great potential in advancing food mycotoxin safety control.

Abstract Image

利用工程各向异性等离子体尖金纳米立方体操纵近红外吸收,用于T-2毒素的高效双反应免疫检测
将特异性免疫识别、理想的消光系数和显著的光热转换能力整合到单个免疫探针中以提高分析性能是一项具有吸引力但具有重大挑战性的任务。本文通过精细地操纵等离子体纳米粒子的几何形状,使其从球形变为尖状,采用基于精确工程方法的尖状金纳米立方体(S-AuNCs)来解决这一挑战,充分利用了等离子体共振吸收诱导的光热效应。采用时域有限差分(FDTD)方法对电磁场和热场进行了计算模拟,并对调节等离子体共振增强光热吸收的可行性进行了评估。优化后的高贵光热剂同时具有良好的近红外吸收(NIR),显著提高808 nm消光系数(比AuNPs高145倍),良好的抗体偶联能力和良好的光热转化行为。因此,s- auncs引导的比色法和光热侧流免疫分析法(CPLFIA)对T-2毒素的灵敏检测具有令人满意的性能。与球形AuNPs (35.2 pg/mL)相比,双模检测灵敏度分别提高了1.862倍和5.18倍,检出限分别为18.9 pg/mL(比色模式)和6.8 pg/mL(光热模式)。因此,s- auncs引导的CPLFIA在推进食品霉菌毒素安全控制方面具有很大的潜力。
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来源期刊
Analytical Chemistry
Analytical Chemistry 化学-分析化学
CiteScore
12.10
自引率
12.20%
发文量
1949
审稿时长
1.4 months
期刊介绍: Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.
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