The effectiveness of onodera`s prognostic nutritional in predicting the prognosis of tongue squamous cell carcinoma.

IF 2.2 3区医学 Q2 Dentistry

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-12-13 DOI:10.1016/j.jormas.2024.102201

Satoshi Fukuzawa, Kenji Yamagata, Ryo Takasaki, Fumihiko Uchida, Naomi Ishibashi-Kanno, Hiroki Bukawa

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引用次数: 0

Abstract

Purpose: To clarify the effects of preoperative nutritional evaluation on the prognosis of patients with tongue squamous cell carcinoma.

Methods: This retrospective cohort study involves 126 consecutive patients who underwent radical surgery as their initial treatment and received treatment for more than 3 years. The markers considered in this study are GGT (γ-GTP), CAR (C-reactive protein (CRP)-to-Alb Ratio), GLR (GGT-to-Lymphocytes Ratio), GPR (GGT-to-Platelet ratio), GNR (GGT-to-Neutrophil ratio), NLR (Neutrophil-to-Lymphocyte ratio), PLR (platelet-to-lymphocytes ratio), OPNI (Onodera`s prognostic nutritional index), PINI (Prognostic Immune and Nutritional Index) and Albumin (Alb). Each marker was calculated from blood test results up to one month before the initial surgery to assess overall survival (OS) and disease-free survival (DFS).

Results: Univariate analysis of OS identified the depth of invasion (DOI P=0.004), stage classification (P<0.001), Body mass index (BMI) (P=0.007), OPNI (P=0.005), prognostic inflammatory and nutritional indices (PINI, P=0.011), and albumin (Alb) (P = 0.006) as significant predictors. Cox regression analysis revealed significant differences in BMI, pathological grade, and OPNI. The OPNI cut-off value was 51.05, indicating its effectiveness in predicting tongue cancer prognosis. With regard to DFS, only BMI showed a significant difference, with no notable difference among other markers.

Conclusion: The OPNI may be a useful prognostic factor for tongue cancer.

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目的：明确术前营养评估对舌鳞癌患者预后的影响：这项回顾性队列研究涉及 126 名连续接受根治性手术作为初始治疗并接受治疗 3 年以上的患者。本研究中考虑的指标包括 GGT（γ-GTP）、CAR（C-反应蛋白（CRP）-to-Alb 比值）、GLR（GGT-to-淋巴细胞比值）、GPR（GGT-to-血小板比值）、GNR（GGT-to-中性粒细胞比值）、NLR（中性粒细胞与淋巴细胞比率）、PLR（血小板与淋巴细胞比率）、OPNI（Onodera 预后营养指数）、PINI（预后免疫和营养指数）和白蛋白（Alb）。每个指标都是根据首次手术前一个月的血液检测结果计算得出，以评估总生存期（OS）和无病生存期（DFS）：结果：OS的单变量分析确定了浸润深度（DOI P=0.004）、分期分类（PC结论：OPNI可能对癌症患者的生存有帮助：OPNI可能是舌癌的一个有用预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.