Sarcopenia in trauma patients: A systematic review and meta-analysis

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-02-01 DOI:10.1016/j.arr.2024.102628

Jin-Zhi Zhang , Chang-Hai Liu , Ya-Lin Shen , Xiao-Na Song , Hong Tang , Hong Li

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Abstract

Sarcopenia is associated with poor prognosis and mortality following injury. This systematic review and meta-analysis aimed to analyze diagnostic criteria for sarcopenia, as well as to assess its prevalence and impact on health outcomes among trauma patients. We conducted a literature search on MEDLINE, EMBASE, and the Cochrane Library from inception to June 2023. A total of 27 studies were included, involving 8692 individuals (55.5 % men) with a mean age ranging from 42.2 to 80.5 years. The pooled prevalence of sarcopenia in trauma patients was 36.0 % [95 % confidence interval (CI): 29.1–43.0 %, I² = 97.8 %], with a 39.3 % prevalence (95 % CI: 31.0–48.5 %, I² = 96.8 %) in men and a 39.0 % prevalence (95 % CI: 31.4–46.2 %, I² = 94.4 %) in women. Trauma patients with sarcopenia were more prone to complications [risk ratio (RR): 1.16, 95 % CI: 1.03–1.31, I² = 45.8 %] and less able to discharge independently (RR: 0.74, 95 % CI: 0.63–0.86, I² = 33.3 %). The risk of death in trauma patients with sarcopenia was higher than in non-sarcopenic patients [hazard ratio (HR): 1.64, 95 % CI: 1.31–2.04]. Sarcopenia is commonly present in trauma patients and has a negative impact on prognosis. Early assessment and interventions for sarcopenia should be conducted in trauma patients.

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创伤患者的 "肌少症"：系统回顾与荟萃分析。

骨骼肌减少症与损伤后的不良预后和死亡率有关。本系统综述和荟萃分析旨在分析肌肉减少症的诊断标准，并评估其在创伤患者中的患病率及其对健康结局的影响。我们在MEDLINE、EMBASE和Cochrane图书馆进行了文献检索，检索时间从成立到2023年6月。共纳入27项研究，涉及8692名个体（55.5%为男性），平均年龄在42.2至80.5岁之间。创伤患者肌肉减少症的总患病率为36.0%[95%可信区间（CI）： 29.1-43.0%, I2 = 97.8%]，其中男性为39.3% (95% CI: 31.0-48.5%, I2 = 96.8%)，女性为39.0% （95% CI: 31.4-46.2%, I2 = 94.4%）。创伤性肌少症患者更容易出现并发症[危险比（RR）： 1.16, 95% CI: 1.03-1.31, I2 = 45.8%]，独立出院能力较差（RR: 0.74, 95% CI: 0.63-0.86, I2 = 33.3%）。创伤合并肌肉减少症患者的死亡风险高于非肌肉减少症患者[风险比（HR）： 1.64, 95% CI: 1.31-2.04]。骨骼肌减少症常见于创伤患者，对预后有不良影响。创伤患者应进行肌肉减少症的早期评估和干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.