Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network level

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-01-01 DOI:10.1016/j.brainresbull.2024.111169

Yuke Zhong, Ying Liu, Huahua Su, Hang Liu, Guohui Liu, Zhihui Liu, Jiahao Wei, Junyi Wang, Yuchen She, Changhong Tan, Lijuan Mo, Lin Han, Fen Deng, Xi Liu, Lifen Chen

{"title":"Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network level","authors":"Yuke Zhong, Ying Liu, Huahua Su, Hang Liu, Guohui Liu, Zhihui Liu, Jiahao Wei, Junyi Wang, Yuchen She, Changhong Tan, Lijuan Mo, Lin Han, Fen Deng, Xi Liu, Lifen Chen","doi":"10.1016/j.brainresbull.2024.111169","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Resting tremor in Parkinson’s disease (PD) is associated with the activity in the basal ganglia and cerebello-thalamo-cortical circuits/network. However, most insights stem from functional MRI research, and structural studies, which can provide basis for and constrain functional activity, remains limited.</div></div><div><h3>Methods</h3><div>We investigated the structural change in PD patients with resting tremor (PD-W<em>R</em>) from a network perspective. 42 early-stage PD-W<em>R</em>, 27 PD patients without resting tremor (PD-NR), and 56 healthy controls (HC) were included.</div></div><div><h3>Results</h3><div>PD-W<em>R</em> showed lower cortical thickness in several motor-related lobules. Compared to HC, significant atrophy was found in right lobule VIIA (t = -3.076, p = 0.016, Cohen's d = 0.627), left lobule VI (t = -3.323, p = 0.007, Cohen's d = 0.678), and right lobule VI (t = -3.052, p = 0.017, Cohen's d = 0.623) in PD-W<em>R</em>. Compared to PD-NR, left lobule V also had a significant reduction (t = -2.958, p = 0.023, d = −0.657). PD-W<em>R</em> had higher fractional anisotropy in cerebello-cortical connection compared to HC (t = 3.209, p = 0.009, d = 0.926), with reduced radial (t = -2.561, p = 0.046, d = 0.739) and mean (t = 2.614, p = 0.046, d = 0.871) diffusivity compared to PD-NR. At the network level, better hierarchy (rho = 0.598, p = 0.004), small-worldness (rho = 0.621, p = 0.003), and increased nodal involvement of the thalamus (rho = 0.718, p = 0.031) and motor cortex (rho = 0.660, p = 0.055) were positively correlated with tremor amplitude.</div></div><div><h3>Conclusion</h3><div>Our study supports the alternation of the cerebello-thalamo-cortical circuit in PD-W<em>R</em>. However, further research with other forms of PD, a wide range of disease stage and larger sample size is needed.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"220 ","pages":"Article 111169"},"PeriodicalIF":3.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Research Bulletin","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0361923024003034","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Resting tremor in Parkinson’s disease (PD) is associated with the activity in the basal ganglia and cerebello-thalamo-cortical circuits/network. However, most insights stem from functional MRI research, and structural studies, which can provide basis for and constrain functional activity, remains limited.

Methods

We investigated the structural change in PD patients with resting tremor (PD-WR) from a network perspective. 42 early-stage PD-WR, 27 PD patients without resting tremor (PD-NR), and 56 healthy controls (HC) were included.

Results

PD-WR showed lower cortical thickness in several motor-related lobules. Compared to HC, significant atrophy was found in right lobule VIIA (t = -3.076, p = 0.016, Cohen's d = 0.627), left lobule VI (t = -3.323, p = 0.007, Cohen's d = 0.678), and right lobule VI (t = -3.052, p = 0.017, Cohen's d = 0.623) in PD-WR. Compared to PD-NR, left lobule V also had a significant reduction (t = -2.958, p = 0.023, d = −0.657). PD-WR had higher fractional anisotropy in cerebello-cortical connection compared to HC (t = 3.209, p = 0.009, d = 0.926), with reduced radial (t = -2.561, p = 0.046, d = 0.739) and mean (t = 2.614, p = 0.046, d = 0.871) diffusivity compared to PD-NR. At the network level, better hierarchy (rho = 0.598, p = 0.004), small-worldness (rho = 0.621, p = 0.003), and increased nodal involvement of the thalamus (rho = 0.718, p = 0.031) and motor cortex (rho = 0.660, p = 0.055) were positively correlated with tremor amplitude.

Conclusion

Our study supports the alternation of the cerebello-thalamo-cortical circuit in PD-WR. However, further research with other forms of PD, a wide range of disease stage and larger sample size is needed.

查看原文本刊更多论文

-早期帕金森病伴静息性震颤在节点、边缘和网络水平上的结构变化。

背景：帕金森病（PD）的静止性震颤与基底神经节和大脑丘脑-皮层回路/网络的活动有关。然而，大多数见解都来自功能性核磁共振成像研究，而可为功能性活动提供依据和制约的结构研究仍然有限：我们从网络角度研究了静止性震颤（PD-WR）患者的结构变化。研究对象包括 42 名早期 PD-WR、27 名无静止性震颤的 PD 患者（PD-NR）和 56 名健康对照组（HC）：结果发现：PD-WR 患者的几个运动相关脑叶的皮质厚度较低。与健康对照组相比，PD-WR 右侧 VIIA 小叶（t = -3.076，p = 0.016，Cohen's d = 0.627）、左侧 VI 小叶（t = -3.323，p = 0.007，Cohen's d = 0.678）和右侧 VI 小叶（t = -3.052，p = 0.017，Cohen's d = 0.623）出现明显萎缩。与 PD-NR 相比，左侧小叶 V 也显著减少（t = -2.958，p = 0.023，d = -0.657）。与 HC（t = 3.209，p = 0.009，d = 0.926）相比，PD-WR 的脑岛-皮层连接分数各向异性更高，与 PD-NR 相比，径向（t = -2.561，p = 0.046，d = 0.739）和平均（t = 2.614，p = 0.046，d = 0.871）扩散性降低。在网络水平上，更好的层次性（rho = 0.598，p = 0.004）、小世界性（rho = 0.621，p = 0.003）以及丘脑（rho = 0.718，p = 0.031）和运动皮层（rho = 0.660，p = 0.055）结节参与的增加与震颤幅度呈正相关：结论：我们的研究支持震颤性肢体运动障碍中大脑-丘脑-皮层回路的交替。结论：我们的研究证实了帕金森病-WR中大脑小脑-皮层回路的交替，但还需要对其他形式的帕金森病、广泛的疾病分期和更大的样本量进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.