Whole-brain functional connectivity and structural network properties in stroke patients with hemiplegia.

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience Pub Date : 2025-01-26 Epub Date: 2024-12-09 DOI:10.1016/j.neuroscience.2024.12.016

Xuejin Cao, Zan Wang, Hongxing Wang, Hengrui Zhou, Jia Quan, Xiaohui Chen, Xi Yang, Shenghong Ju, Yuancheng Wang, Yijing Guo

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引用次数: 0

Abstract

Objective: This study explored structural and functional alterations in the whole brain of stroke patients with hemiplegia.

Methods: We collected multimodal magnetic resonance images of 24 patients with ischaemic stroke and 16 age-matched controls. Resting-state functional connectivity (FC) for all brain regions was evaluated. Diffusion tensor imaging was used to construct white matter structural networks, and the graph properties of the structural network were analysed using graph theory to determine group differences.

Results: The ipsilesional posterior parietal cortex (PPC) in the frontoparietal network accounts for more than half of the 25 brain regions with altered FC in stroke patients. The nodal efficiency of multiple ipsilesional frontal lobes and cerebellar regions, such as the ipsilateral cerebellum 8, was reduced. The contralesional cerebellum 8 showed elevated FC with the lingual gyrus and the visual network.

Conclusions: Our results suggest that the PPC and cerebellum 8 are regions worthy of in-depth study. The cerebellum 8 may supplement deficits in motor balance function by enhancing functional congruence with the visual area.

Significance: This study identified key brain regions and characteristics that exhibit structural and functional changes following stroke injury.

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脑卒中偏瘫患者的全脑功能连通性和结构网络特性。

目的：探讨脑卒中偏瘫患者全脑结构和功能的改变。方法：收集24例缺血性脑卒中患者的多模态磁共振图像和16例年龄匹配的对照组。评估各脑区静息状态功能连通性（FC）。利用扩散张量成像技术构建白质结构网络，利用图论分析结构网络的图性质，确定群体差异。结果：脑卒中患者额顶叶网络中的同侧后顶叶皮层（PPC）占25个脑区FC改变的一半以上。同侧额叶和小脑等多个区域的节效率降低。对侧小脑8伴舌回和视觉网络的FC升高。结论：我们的结果提示PPC和小脑8是值得深入研究的区域。小脑8可以通过增强与视觉区域的功能一致性来补充运动平衡功能的缺陷。意义：本研究确定了脑卒中损伤后表现出结构和功能变化的关键脑区域和特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience 医学-神经科学

CiteScore

6.20

自引率

0.00%

发文量

394

审稿时长

52 days

期刊介绍： Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.