Dose-dependent effects of alcohol consumption on pressure pain threshold

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors Pub Date : 2024-12-04 DOI:10.1016/j.addbeh.2024.108226

Jeff Boissoneault , Adriana Cushnie , Madison Sinclair , Sage Hebert , Rachel Schorn , Jonathan Burt , Riley Dougherty

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引用次数: 0

Abstract

Introduction

Prior laboratory-based studies have identified significant analgesic effects of acute alcohol. Despite providing excellent experimental control, these studies are limited regarding the range of alcohol exposure that can be practically and ethically achieved. This study capitalized on the heterogeneity in breath alcohol concentration (BrAC) resulting from naturalistic alcohol use at a public event to improve understanding of alcohol analgesia. We hypothesized that BrAC would be significantly and positively associated with pain threshold.

Methods

Participants were attendees of the 2024 Minnesota State Fair reporting alcohol use within the last month (N = 149, 55 % women). Each completed a brief assessment of pressure pain threshold at the first dorsal interosseus muscle. BrAC was measured using a standard breathalyzer device. Hierarchical multiple regression analysis characterized BrAC as a predictor of pain threshold, controlling for covariates including clinical pain, age, sex, typical drinking, participant/experimenter gender matching, and expectancies of alcohol analgesia.

Results

30.9 % of participants had non-zero BrACs, with an average of 0.038 g/dL. Average pain threshold was 3.58 kgf/cm². Higher BrAC predicted greater pain threshold in both the whole sample (b = 0.145, p = 0.001, η²_p = 0.07) and those participants with non-zero BrACs (b = 0.184, p = 0.009, η²_p = 0.18). Men had significant greater pain thresholds than women (p = 0.007, η²_p = 0.052), but no other covariates reached significance. Addition of quadratic and cubic BrAC terms did not improve model fit.

Discussion

Results suggest a significant, dose-dependent association of alcohol use with increased pain threshold, independent of age, sex, number of reported pain conditions, participant/experimenter gender matching, or beliefs regarding alcohol analgesia. The acute analgesic effects of alcohol may scale linearly with amount consumed, at least within the BrAC range observed in the study.

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酒精摄入对压力痛阈的剂量依赖性影响。

先前基于实验室的研究已经确定了急性酒精的显著镇痛作用。尽管这些研究提供了良好的实验控制，但在实际和道德上可以实现的酒精暴露范围方面，这些研究是有限的。本研究利用在公共场合自然饮酒引起的呼吸酒精浓度（BrAC）的异质性来提高对酒精镇痛的理解。我们假设BrAC与疼痛阈值显著正相关。方法：参与者是在上个月报告饮酒的2024年明尼苏达州博览会的参与者（N = 149, 55%为女性）。每个人都完成了第一背骨间肌压力痛阈的简短评估。BrAC使用标准呼气测醉仪测量。分层多元回归分析表明BrAC是疼痛阈值的预测因子，控制了包括临床疼痛、年龄、性别、典型饮酒、参与者/实验者性别匹配和酒精镇痛预期在内的协变量。结果：30.9%的参与者具有非零brac，平均为0.038 g/dL。平均疼痛阈值为3.58 kgf/cm2。BrAC越高，整个样本（b = 0.145, p = 0.001, η2p = 0.07）和非BrAC为零的参与者（b = 0.184, p = 0.009, η2p = 0.18）的疼痛阈值越高。男性的疼痛阈值显著高于女性（p = 0.007, η2p = 0.052），但其他协变量均无显著性差异。二次和三次BrAC项的加入并没有改善模型拟合。讨论：结果表明，酒精使用与疼痛阈值增加存在显著的剂量依赖性关联，与年龄、性别、报告的疼痛状况数量、参与者/实验者性别匹配或关于酒精镇痛的信念无关。至少在研究中观察到的BrAC范围内，酒精的急性镇痛作用可能与饮酒量成线性关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.