Hallmarks of aging: A user’s guide for comparative biologists

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-02-01 DOI:10.1016/j.arr.2024.102616

Peggy R. Biga , Jingyue E. Duan , Tristan E. Young , Jamie R. Marks , Anne Bronikowski , Louis P. Decena , Eric C. Randolph , Ananya G. Pavuluri , Guangsheng Li , Yifei Fang , Gerald S. Wilkinson , Gunjan Singh , Nathan T. Nigrin , Erica N. Larschan , Andrew J. Lonski , Nicole C. Riddle , IISAGE Consortium

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引用次数: 0

Abstract

Since the first description of a set of characteristics of aging as so-called hallmarks or pillars in 2013/2014, these characteristics have served as guideposts for the research in aging biology. They have been examined in a range of contexts, across tissues, in response to disease conditions or environmental factors, and served as a benchmark for various anti-aging interventions. While the hallmarks of aging were intended to capture generalizable characteristics of aging, they are derived mostly from studies of rodents and humans. Comparative studies of aging including species from across the animal tree of life have great promise to reveal new insights into the mechanistic foundations of aging, as there is a great diversity in lifespan and age-associated physiological changes. However, it is unclear how well the defined hallmarks of aging apply across diverse species. Here, we review each of the twelve hallmarks of aging defined by Lopez-Otin in 2023 with respect to the availability of data from diverse species. We evaluate the current methods used to assess these hallmarks for their potential to be adapted for comparative studies. Not unexpectedly, we find that the data supporting the described hallmarks of aging are restricted mostly to humans and a few model systems and that no data are available for many animal clades. Similarly, not all hallmarks can be easily assessed in diverse species. However, for at least half of the hallmarks, there are methods available today that can be employed to fill this gap in knowledge, suggesting that these studies can be prioritized while methods are developed for comparative study of the remaining hallmarks.

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衰老的标志：比较生物学家用户指南。

自2013/2014年首次将衰老的一系列特征描述为所谓的标志或支柱以来，这些特征已成为衰老生物学研究的路标。它们已经在各种背景下，跨组织，对疾病状况或环境因素的反应中进行了研究，并作为各种抗衰老干预措施的基准。虽然衰老的特征是为了捕捉衰老的一般特征，但它们主要来自对啮齿动物和人类的研究。衰老的比较研究，包括来自整个动物生命树的物种，有很大的希望揭示衰老的机制基础的新见解，因为寿命和年龄相关的生理变化有很大的多样性。然而，目前还不清楚这些衰老特征在不同物种中的适用程度。在这里，我们回顾了Lopez-Otin在2023年根据不同物种数据的可用性定义的12个衰老标志。我们评估了目前用于评估这些特征的方法，以确定其适用于比较研究的潜力。不出意外的是，我们发现支持上述衰老特征的数据主要局限于人类和一些模型系统，而许多动物分支的数据都是不可用的。同样，并非所有的特征都能在不同的物种中轻易地被评估。然而，对于至少一半的特征，今天有可用的方法可以用来填补这一知识空白，这表明这些研究可以优先考虑，同时开发方法用于对剩余特征的比较研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.