Glia–glia crosstalk via semaphorins: Emerging implications in neurodegeneration

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-02-01 DOI:10.1016/j.arr.2024.102618

Claudia Palazzo , Sofia Nutarelli , Roberta Mastrantonio , Luca Tamagnone , Maria Teresa Viscomi

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引用次数: 0

Abstract

The central nervous system (CNS) is wired by a complex network of integrated glial and neuronal signals, which is critical for its development and homeostasis. In this context, glia-glia communication is a complex and dynamic process that is essential for ensuring optimal CNS function. Semaphorins, which include secreted and transmembrane molecules, and their receptors, mainly found in the plexin and neuropilin families, are expressed in a wide range of cell types, including glia. In the CNS, semaphorin signalling is involved in a spectrum of processes, including neurogenesis, neuronal migration and wiring, and glial cell recruitment. Recently, semaphorins and plexins have attracted intense research aimed at elucidating their roles in instructing glial cell behavior during development or in response to inflammatory stimuli. In this review, we provide an overview of the multifaceted role of semaphorins in glia–glia communication, highlighting recent discoveries about semaphoring-dependent regulation of glia functions in healthy conditions. We also discuss the mechanisms of gliaglia crosstalk mediated by semaphorins under pathological conditions, and how these interactions may provide potential avenues for therapeutic intervention in neuroinflammation-mediated neurodegeneration.

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信号素介导的神经胶质细胞串扰：神经退行性变的新意义。

中枢神经系统（CNS）是由神经胶质和神经元信号组成的复杂网络连接起来的，这对中枢神经系统的发育和稳态至关重要。在这种情况下，胶质细胞间的交流是一个复杂的动态过程，对于确保最佳中枢神经系统功能至关重要。信号蛋白包括分泌分子和跨膜分子，其受体主要存在于丛蛋白和神经磷脂家族中，在包括胶质细胞在内的多种细胞类型中表达。在中枢神经系统中，信号素信号参与了一系列过程，包括神经发生、神经元迁移和连接以及胶质细胞募集。最近，信号蛋白和神经丛蛋白引起了广泛的研究，旨在阐明它们在发育过程中指导神经胶质细胞行为或对炎症刺激的反应中的作用。在这篇综述中，我们概述了信号蛋白在胶质细胞间通讯中的多方面作用，重点介绍了在健康条件下信号依赖调节胶质细胞功能的最新发现。我们还讨论了病理条件下信号蛋白介导的胶质细胞串扰的机制，以及这些相互作用如何为神经炎症介导的神经退行性疾病的治疗干预提供潜在的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.