Rice bran peptides target lectin-like oxidized low-density lipoprotein receptor-1 to ameliorate atherosclerosis†

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Food & Function Pub Date : 2024-11-25 DOI:10.1039/D4FO04514A
Jianfei Mu, Jiajia Li, Zhongxu Chen, Yajuan Chen, Qinlu Lin, Lingyu Zhang, Yong Fang and Ying Liang
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引用次数: 0

Abstract

Food-derived multifunctional peptides offer numerous health benefits through different biochemical pathways. However, their impact on aging-related atherosclerotic cardiovascular disease (ASCVD), especially atherosclerosis, remains underexplored despite cardiovascular disease (CVD) being the leading cause of death globally. In this study, NHANES data and Mendelian randomization were used to analyze the association between lipid metabolism disorders, systemic immune responses, dietary inflammatory index, and ASCVD. The results showed that they were all positively correlated with ASCVD. A dietary intervention was used to induce a mouse model of atherosclerosis through a high-fat diet (HFD). Our findings demonstrate that rice bran peptide could mitigate the typical pathological features of atherosclerosis. Molecular docking analysis further predicted that lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a key target of rice bran peptide. This prediction was validated through a two-cell model of endothelial cells and lox-1-interfered macrophages. Therefore, targeting LOX-1 with rice bran peptide inhibits the excessive uptake of oxidized LDL (ox-LDL) by macrophages, thereby hindering the mass production of foam cells, which is crucial in preventing the early onset of atherosclerosis.

Abstract Image

米糠肽靶向凝集素样氧化低密度脂蛋白受体-1改善动脉粥样硬化。
食物来源的多功能肽通过不同的生化途径提供许多健康益处。然而,尽管心血管疾病(CVD)是全球死亡的主要原因,但它们对衰老相关的动脉粥样硬化性心血管疾病(ASCVD),特别是动脉粥样硬化的影响仍未得到充分研究。在这项研究中,使用NHANES数据和孟德尔随机化来分析脂质代谢紊乱、全身免疫反应、饮食炎症指数和ASCVD之间的关系。结果表明,它们均与ASCVD呈正相关。采用饮食干预方法,通过高脂饮食(HFD)诱导小鼠动脉粥样硬化模型。我们的研究结果表明,米糠肽可以减轻动脉粥样硬化的典型病理特征。分子对接分析进一步预测,凝集素样氧化低密度脂蛋白受体-1 (LOX-1)是米糠肽的关键靶点。通过内皮细胞和lox-1干扰巨噬细胞的双细胞模型验证了这一预测。因此,米糠肽靶向LOX-1可抑制巨噬细胞对氧化LDL (ox-LDL)的过度摄取,从而阻碍泡沫细胞的大量产生,这对预防动脉粥样硬化的早期发生至关重要。
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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
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