The complete telomere-to-telomere sequence of a mouse genome

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2024-12-05 DOI:10.1126/science.adq8191

Junli Liu, Qilin Li, Yixuan Hu, Yi Yu, Kai Zheng, Dengfeng Li, Lexin Qin, Xiaochun Yu

引用次数: 0

Abstract

The current reference genome of Mus musculus , GRCm39, has major gaps in both euchromatic and heterochromatic regions associated with repetitive sequences. In this work, we have sequenced and assembled the telomere-to-telomere genome of mouse haploid embryonic stem cells. The results reveal more than 7.7% of previously uncovered sequences of the mouse genome, including ribosomal DNA arrays and pericentromeric and subtelomeric regions, as well as an additional 140 genes predicted to be protein-coding. This study helps to address knowledge gaps in the mouse genome.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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