The role of super-enhancers in head and neck cancer and its potential therapeutic targets

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-12-02 DOI:10.1016/j.jormas.2024.102182

Chuhuan Zhou, Gunan Guo, Qi Li

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Abstract

Head and neck squamous cell carcinoma (HNSCC) poses a significant global health challenge, with over 660,000 new cases diagnosed and more than 325,000 deaths each year. Despite advances in treatment, long-term survival rates for HNSCC patients remain disappointingly low, underscoring the critical need for innovative therapeutic strategies. This review delves into the role of super-enhancers in HNSCC, highlighting their pivotal function in regulating key oncogenes such as KLF4, FOSL1, and ΔNp63, which are crucial for tumor progression and metastasis. Moreover, it explores how super-enhancers contribute to the maintenance of cancer stem cell characteristics by controlling genes like SOX2, BRD4. thereby promoting self-renewal and pluripotency.The study also underscores the potential of BET bromodomain inhibitors, exemplified by JQ1, and CDK7 inhibitors like THZ1, which demonstrate substantial therapeutic promise by effectively disrupting the function of super-enhancers in HNSCC. Overall, this research provides a comprehensive overview of the importance of super-enhancers in HNSCC.

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超级增强剂在头颈癌中的作用及其潜在的治疗靶点。

头颈部鳞状细胞癌（HNSCC）对全球健康构成重大挑战，每年有66万多例新诊断病例和32.5万多例死亡。尽管在治疗方面取得了进展，但HNSCC患者的长期生存率仍然低得令人失望，这强调了对创新治疗策略的迫切需要。本综述深入探讨了超级增强子在HNSCC中的作用，强调了它们在调节关键癌基因（如KLF4、FOSL1和ΔNp63）中的关键功能，这些癌基因对肿瘤的进展和转移至关重要。此外，它还探讨了超级增强子如何通过控制SOX2、BRD4等基因来促进癌症干细胞特征的维持。从而促进自我更新和多能性。该研究还强调了BET溴结构域抑制剂的潜力，例如JQ1和CDK7抑制剂如THZ1，它们通过有效破坏HNSCC中超增强子的功能而显示出巨大的治疗前景。总的来说，本研究提供了超级增强剂在HNSCC中的重要性的全面概述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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