Analysis of data from the NHANES 1999-2018 and Mendelian randomization studies reveals the relationship between alcohol use and rheumatoid arthritis.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-12-05 DOI:10.1186/s12937-024-01057-6

Xiaobing Yang, Xiaoqin Long, Pan Xiao, Qinwen Ge, Lei Zhang, Xiaowei Wang

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引用次数: 0

Abstract

Background: Rheumatoid arthritis (RA) is a complex multifactorial autoimmune disease affected by genetics and environmental factors. The relationship between alcohol consumption and RA remains controversial. This study aimed to assess the association between alcohol consumption and RA risk using cross-sectional analysis and Mendelian randomization (MR).

Methods: We investigated the association between alcohol consumption and RA risk through multivariate linear regression and subgroup analyses. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 which involved 32,308 participants. Subsequently, a two-sample MR study was conducted to assess the causal effect of spirits intake on RA. Instrumental variables (IVs) for spirits intake were screened from genome-wide association study (GWAS) datasets, including 69,949 individuals from the UK Biobank study, while summary statistics relating to RA were obtained from a GWAS meta-analysis of 417,256 participants. The primary inverse variance weighted (IVW) method and other supplementary MR methods were used to estimate the causal association between spirits intake and RA. Sensitivity analyses were performed to confirm the robustness and reliability of the results.

Results: In the cross-sectional analysis, we observed that alcohol consumption was significantly positively linked with RA risk (odds ratio [OR] = 1.030; 95% confidence interval [CI], 1.025-1.034). According to subgroup analyses stratified by age, sex, race, smoking status, marital status, education attainment, and body mass index (BMI), consistently showed a positive relationship between alcohol consumption and RA risk in each subgroup (all OR > 1, P < 0.05). Furthermore, MR analysis indicated a causal association between spirits intake and RA (OR = 1.043, P < 0.05). Sensitivity analyses supported the robustness and reliability of these findings (all P > 0.05).

Conclusion: This study indicated that alcohol consumption is correlated with an increased risk of RA, but further studies are necessary to clarify the exact association.

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对NHANES 1999-2018年和孟德尔随机化研究数据的分析揭示了酒精使用与类风湿性关节炎之间的关系。

背景：类风湿性关节炎（RA）是一种受遗传和环境因素影响的复杂多因素自身免疫性疾病。饮酒与类风湿性关节炎之间的关系仍然存在争议。本研究旨在通过横断面分析和孟德尔随机化（MR）来评估饮酒与类风湿性关节炎风险之间的关系。方法：我们通过多元线性回归和亚组分析来调查饮酒与类风湿性关节炎风险之间的关系。数据来自1999-2018年国家健康和营养检查调查（NHANES），涉及32308名参与者。随后，进行了一项双样本MR研究，以评估酒精摄入对RA的因果影响。从全基因组关联研究（GWAS）数据集中筛选酒精摄入量的工具变量（IVs），其中包括来自英国生物银行研究的69,949名个体，而与RA相关的汇总统计数据来自417,256名参与者的GWAS荟萃分析。主要反方差加权（IVW）方法和其他补充MR方法用于估计酒精摄入量与RA之间的因果关系。进行敏感性分析以确认结果的稳健性和可靠性。结果：在横断面分析中，我们观察到饮酒与RA风险显著正相关(优势比[OR] = 1.030；95%可信区间[CI]， 1.025-1.034)。根据年龄、性别、种族、吸烟状况、婚姻状况、受教育程度和身体质量指数（BMI）分层的亚组分析，每个亚组一致显示饮酒与RA风险呈正相关（均比为0.01,P < 0.05）。结论：本研究表明，饮酒与RA风险增加相关，但需要进一步的研究来阐明确切的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.