Sex differences in the association between dietary choline intake and total bone mineral density among adolescents aged 12-19 in the United States.

IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS
Frontiers in Nutrition Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI:10.3389/fnut.2024.1459117
Hongyang Gong, Jiecheng Jiang, Seok Choi, Shaoqun Huang
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引用次数: 0

Abstract

Background: While prior research has established a correlation between dietary choline intake and bone density in the elderly, the relationship in adolescents remains ambiguous. This study seeks to examine the association between dietary choline intake and bone density in American adolescents.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) for 2005 to 2018 were used in this study, encompassing participants aged 12-19 years. The relationship between dietary choline intake and bone density was assessed using multivariate linear regression models and restricted cubic spline (RCS) models. Subgroup analyses were also performed to investigate differences across various subgroups.

Results: 3,800 participants with an average age of 15 years were included in this study. After adjusting for relevant confounding factors, a positive correlation was observed between dietary choline intake and total bone density in adolescents (95% CI: 0.03-0.17, p = 0.010). Gender-specific analysis indicated a significant positive correlation between dietary choline intake and total bone density in males (95% CI: 0.07-0.23, p < 0.001), while no significant correlation was found in females (95% CI: -0.19 to 0.09, p = 0.500). The stratified analysis revealed that the positive association was more pronounced in males and non-Hispanic whites (interaction p < 0.05). The restricted cubic spline model demonstrated a linear positive correlation between dietary choline intake and total bone density.

Conclusion: This study demonstrates that dietary choline intake levels are positively correlated with bone density in adolescents, with this association being specific to males.

美国12-19岁青少年饮食胆碱摄入量与总骨密度之间关系的性别差异
背景:虽然先前的研究已经建立了老年人饮食胆碱摄入量与骨密度之间的相关性,但在青少年中的关系仍然不明确。本研究旨在研究美国青少年饮食胆碱摄入量与骨密度之间的关系。方法:本研究使用2005年至2018年国家健康与营养检查调查(NHANES)的数据,包括12-19岁的参与者。采用多元线性回归模型和限制性三次样条(RCS)模型评估饮食胆碱摄入量与骨密度之间的关系。还进行了亚组分析,以调查不同亚组之间的差异。结果:3800名平均年龄为15岁的参与者被纳入本研究。在校正相关混杂因素后,青少年膳食胆碱摄入量与总骨密度呈正相关(95% CI: 0.03-0.17, p = 0.010)。性别分析表明,男性膳食胆碱摄入量与总骨密度之间存在显著正相关(95% CI: 0.07-0.23, p = 0.500)。分层分析显示,男性和非西班牙裔白人之间的正相关关系更为明显(相互作用)。结论:本研究表明,青少年饮食胆碱摄入量水平与骨密度呈正相关,且这种关联仅针对男性。
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来源期刊
Frontiers in Nutrition
Frontiers in Nutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.20
自引率
8.00%
发文量
2891
审稿时长
12 weeks
期刊介绍: No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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