Recent Advances in Enhancing the Sensitivity of Biosensors Based on Field Effect Transistors

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advanced Electronic Materials Pub Date : 2024-12-05 DOI:10.1002/aelm.202400712

Yuying Zhou, Tongshi Feng, Yao Li, Xiang Ao, Shengfa Liang, Xiaonan Yang, Lingfei Wang, Xiaoxin Xu, Wenchang Zhang

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引用次数: 0

Abstract

Biosensors based on field effect transistor (FET), also known as Bio‐FETs, offer numerous advantages, including high sensitivity, rapid response speed, low operating voltage, compact size, high reliability, and easily integrative. These features endow Bio‐FETs with tremendous performance in rapid analysis for samples with ultra‐low concentration at large‐scale, broadening their multiple potential applications. In recent years, the research based on Bio‐FETs has attracted more and more attention. A lot of effort is put into the challenge to improve their sensitivity, which can be influenced by various factors. This review focuses on the current approaches from multiple perspectives, including overcoming the influence of Debye shielding effects, promoting the binding efficiency of analytes and FETs surface, and improving the structures of FETs device. Correspondingly, novel strategies to increase the Debye length, facilitate high frequency electric field modulation, enhance the specific interaction efficiency, and enlarge the specific surface area (SBET) are also summarized. Additionally, there is a lack of a reliable standard method to characterize the sensitivity of FETs currently. Regarding this issue, the most commonly used definitions and representation parameters of sensitivity are also evaluated. Overall, this review outlines the potential future research directions to offer insights for enhancing the sensitivity of Bio‐FETs.

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基于场效应晶体管提高生物传感器灵敏度的研究进展

基于场效应晶体管（FET）的生物传感器，也称为Bio - FET，具有灵敏度高、响应速度快、工作电压低、体积小、可靠性高、易于集成等诸多优点。这些特点赋予了生物场效应管在大规模超低浓度样品快速分析方面的巨大性能，拓宽了它们的多种潜在应用。近年来，基于生物场效应管的研究越来越受到人们的关注。为了提高它们的灵敏度，我们付出了很多努力，而这可能受到各种因素的影响。本文从克服Debye屏蔽效应的影响、提高分析物与fet表面的结合效率、改进fet器件结构等方面综述了目前的研究方法。相应的，总结了增加德拜长度、促进高频电场调制、提高比相互作用效率和扩大比表面积的新策略。此外，目前还缺乏一种可靠的标准方法来表征场效应管的灵敏度。针对这一问题，本文还对最常用的灵敏度定义和表示参数进行了评价。总体而言，本文概述了未来潜在的研究方向，为提高生物效应场效应管的灵敏度提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Electronic Materials NANOSCIENCE & NANOTECHNOLOGYMATERIALS SCIE-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

11.00

自引率

3.20%

发文量

433

期刊介绍： Advanced Electronic Materials is an interdisciplinary forum for peer-reviewed, high-quality, high-impact research in the fields of materials science, physics, and engineering of electronic and magnetic materials. It includes research on physics and physical properties of electronic and magnetic materials, spintronics, electronics, device physics and engineering, micro- and nano-electromechanical systems, and organic electronics, in addition to fundamental research.