Global, regional, and national epidemiology of nasopharyngeal carcinoma in middle-aged and elderly patients from 1990 to 2021

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-02-01 DOI:10.1016/j.arr.2024.102613

Qiqi Liu , Hanyu Wang , Ze Chen , Jiahui Xiong , Yong Huang , Shipeng Zhang , Qinxiu Zhang

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引用次数: 0

Abstract

Background

In recent years, changes in the incidence and mortality rates of nasopharyngeal carcinoma have occurred globally, across various regions, and among different countries. As a high incidence group, it is necessary to study the prevalence trend of middle-aged and elderly people.

Methods

Detailed information on NPC in middle-aged and elderly patients from 1990 to 2021 was collected from the Global Burden of Disease Database 2021 (GBD2021). Adopted incidence, mortality, disability-adjusted life-years (DALYs), sociodemographic index (SDI) and corresponding Estimated Annual Percentage Changes (EAPCs) to assess the burden of NPC in middle-aged and elderly patients. Additionally, a global risk attribution analysis was conducted, and a Bayesian age-period-cohort (BAPC) model was applied to project the global burden of NPC in middle-aged and elderly patients from 2021 to 2035.

Findings

Globally, the incidence cases of NPC in middle-aged and elderly people increased by 58.2 %, the numbers of death increased by 33.8 %, and the DALY increased by 42.1 %. However, the EAPCs values and upper limits in incidence, mortality and DALY rates were all less than 0, indicating a decreasing trend of incidence, mortality and disease burden. Both incidence and mortality rates were decreasing in high-incidence territories. Most regions were negatively correlated with the sociodemographic index. Males had obviously higher incidence and mortality of NPC in middle-aged and elderly patients than females. The highest incidences of nasopharyngeal carcinoma in middle-aged and elderly males were in the 65–69 age group, and the incidences in females did not change much among different age groups. We found that Alcohol use, Occupational risk and Tobacco were the major risk factors for NPC-related mortality in middle-aged and elderly patients.

Conclusion

Controllable etiology should be effectively controlled in the future.

Data availability

The data sets generated and/or analyzed during the current study are available in the GBD repository (https://vizhub.healthdata.org/gbd-results/). Data will be made available on request.

查看原文本刊更多论文

1990年至2021年中老年鼻咽癌患者的全球、地区和国家流行病学

背景：近年来，鼻咽癌的发病率和死亡率在全球、不同地区和不同国家之间发生了变化。中老年人作为高发人群，有必要对其流行趋势进行研究。方法：从全球疾病负担数据库2021 （GBD2021）中收集1990年至2021年中老年NPC患者的详细信息。采用发病率、死亡率、残疾调整生命年（DALYs）、社会人口指数（SDI）及相应的估计年变化百分比（EAPCs）评估中老年鼻咽癌患者的负担。此外，进行了全球风险归因分析，并应用贝叶斯年龄-时期-队列（BAPC）模型预测了2021 - 2035年全球中老年鼻咽癌患者的负担。结果：在全球范围内，中老年人鼻咽癌发病率增加58.2%，死亡人数增加33.8%，DALY增加42.1%。但发病率、死亡率和DALY的EAPCs值和上限均小于0，表明发病率、死亡率和疾病负担呈下降趋势。在高发地区，发病率和死亡率都在下降。大部分地区与社会人口指数呈负相关。中老年鼻咽癌患者男性的发病率和死亡率明显高于女性。中老年男性鼻咽癌发病率以65 ~ 69岁年龄组最高，不同年龄组女性鼻咽癌发病率变化不大。我们发现，酒精使用、职业风险和烟草是中老年患者npc相关死亡的主要危险因素。结论：今后应有效控制可控病因。数据可用性：在当前研究期间生成和/或分析的数据集可在GBD存储库中获得（https://vizhub.healthdata.org/gbd-results/）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.