Abdominal fat accumulation increases the risk of high blood pressure: evidence of 47,037 participants from Chinese and US national population surveys.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2024-12-02 DOI:10.1186/s12937-024-01058-5

Jin-Yu Sun, Zhenyang Su, Hui Shen, Yang Hua, Wei Sun, Xiang-Qing Kong

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引用次数: 0

Abstract

Aims: This study aims to ascertain whether abdominal fat accumulation evaluated by waist circumference increases the risk of hypertension using the nationwide population.

Methods: We enrolled 47,037 participants from the China Health and Nutrition Survey (CHNS), China Health and Retirement Longitudinal Study (CHARLS), and National Health, and Nutrition Examination Survey (NHANES). The adjusted logistic regression model was used to examine the relationship between waist circumference and prevalent hypertension. 9445 participants without baseline hypertension from the CHNS and CHARLS were followed up to investigate the association between waist circumference and onset hypertension. The association was evaluated using a Cox regression model and restricted cubic spline. Furthermore, Mendelian randomization was employed to explore causal inferences.

Results: In the baseline survey, waist circumference demonstrated a notable correlation with hypertension, presenting an odds ratio (with 95% confidence intervals) of 1.34 (1.28 ~ 1.40). After a mean follow-up of 3.8 years for participants without baseline hypertension, 2,592 (27.5%) developed hypertension. In the pooled analysis, the Cox regression showed that every 10 cm increase in waist circumference was associated with 20% (95% CI: 13% ~ 27%) elevated risk of new-onset hypertension. Restricted cubic splines indicated a pronounced linear dose-response relationship. A subgroup analysis affirmed the persisting association between waist circumference and hypertension onset even in those with normal BMI. The Mendelian randomization method revealed a significant causative association between waist circumference and hypertension.

Conclusion: Elevated waist circumference stands as an independent risk factor for hypertension, even in those with normal BMI. Our results provide evidence supporting the routine measure for waist circumference.

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腹部脂肪堆积增加高血压的风险：来自中国和美国全国人口调查的47037名参与者的证据。

目的：本研究旨在通过全国范围内的人群，确定通过腰围来评估腹部脂肪堆积是否会增加高血压的风险。方法：我们从中国健康与营养调查（CHNS）、中国健康与退休纵向研究（CHARLS）和全国健康与营养检查调查（NHANES）中招募了47037名参与者。采用调整后的logistic回归模型检验腰围与高血压的关系。9445名来自CHNS和CHARLS的无基线高血压的参与者进行了随访，以调查腰围与发病高血压之间的关系。使用Cox回归模型和受限三次样条对相关性进行评估。此外，采用孟德尔随机化来探索因果推论。结果：基线调查中，腰围与高血压有显著相关性，比值比（95%可信区间）为1.34（1.28 ~ 1.40）。在没有基线高血压的参与者平均随访3.8年后，2592人（27.5%）发展为高血压。在合并分析中，Cox回归分析显示，腰围每增加10厘米，新发高血压的风险增加20% （95% CI: 13% ~ 27%）。受限三次样条曲线显示出明显的线性剂量-响应关系。一项亚组分析证实，即使在BMI正常的人群中，腰围与高血压发病之间也存在持续的联系。孟德尔随机化方法显示腰围与高血压之间存在显著的因果关系。结论：腰围升高是高血压的独立危险因素，即使在BMI正常的人群中也是如此。本研究结果为常规测量腰围提供了依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.