Yuki Nishi, Koki Ikuno, Yuji Minamikawa, Michihiro Osumi, Shu Morioka
{"title":"Case report: A novel transcutaneous electrical nerve stimulation improves dysesthesias and motor behaviors after transverse myelitis.","authors":"Yuki Nishi, Koki Ikuno, Yuji Minamikawa, Michihiro Osumi, Shu Morioka","doi":"10.3389/fnhum.2024.1447029","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Transverse myelitis (TM)-associated dysesthesia is diverse and frequently resistant to treatment. This study explored the comprehensive effects of a novel transcutaneous electrical nerve stimulation (TENS) approach tailored to an individual's specific dysesthesia profile in a patient with TM.</p><p><strong>Patient and method: </strong>A 52-year-old woman with severe dysesthesias in the left C8 sensory area caused by TM underwent an A-B-A-B-A design intervention. The baseline (phase A) and intervention (phase B) phases were both 7 days. Tingling and allodynia were scored on an 11-point numerical rating scale pre-, post-, and 1 h post-treatment. Upper limb activities during daily living were assessed using a wrist-worn accelerometer. The intervention phase consisted of 60-min sessions of TENS two times daily. Furthermore, the intervention and carry-over effects of TENS were evaluated using Tau-U and Bayesian unknown change point models.</p><p><strong>Results: </strong>The effects of TENS resulted in the immediate improvement in tingling, allodynia, and upper limb activity. Long-term effects of TENS affected tingling and upper limb activity; however, no impacts on allodynia were observed.</p><p><strong>Conclusion: </strong>This novel TENS approach shows promise as an effective treatment, even in rare and treatment-resistant dysesthesia associated with TM.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1447029"},"PeriodicalIF":2.4000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609914/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Human Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnhum.2024.1447029","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: Transverse myelitis (TM)-associated dysesthesia is diverse and frequently resistant to treatment. This study explored the comprehensive effects of a novel transcutaneous electrical nerve stimulation (TENS) approach tailored to an individual's specific dysesthesia profile in a patient with TM.
Patient and method: A 52-year-old woman with severe dysesthesias in the left C8 sensory area caused by TM underwent an A-B-A-B-A design intervention. The baseline (phase A) and intervention (phase B) phases were both 7 days. Tingling and allodynia were scored on an 11-point numerical rating scale pre-, post-, and 1 h post-treatment. Upper limb activities during daily living were assessed using a wrist-worn accelerometer. The intervention phase consisted of 60-min sessions of TENS two times daily. Furthermore, the intervention and carry-over effects of TENS were evaluated using Tau-U and Bayesian unknown change point models.
Results: The effects of TENS resulted in the immediate improvement in tingling, allodynia, and upper limb activity. Long-term effects of TENS affected tingling and upper limb activity; however, no impacts on allodynia were observed.
Conclusion: This novel TENS approach shows promise as an effective treatment, even in rare and treatment-resistant dysesthesia associated with TM.
目的：横贯脊髓炎（TM）相关的感觉障碍是多种多样的，并且经常难以治疗。本研究探讨了一种新的经皮神经电刺激（TENS）方法的综合效果，该方法针对TM患者的个体特定感觉障碍进行了量身定制。患者和方法：一名52岁女性，因TM引起左侧C8感觉区严重感觉障碍，采用A- b -A- b -A设计干预。基线期（A期）和干预期（B期）均为7天。在治疗前、治疗后和治疗后1小时，用11分的数值评定量表对刺痛和异常性痛进行评分。使用腕带加速度计评估日常生活中的上肢活动。干预阶段包括每天两次60分钟的TENS。此外，利用Tau-U和贝叶斯未知变化点模型评估了TENS的干预和延续效应。结果：TENS能立即改善患者的刺痛、异常性痛和上肢活动。TENS对麻刺感和上肢活动的长期影响然而，没有观察到对异常性疼痛的影响。结论：这种新颖的TENS方法有望成为一种有效的治疗方法，即使是罕见的和治疗难治性TM相关的感觉障碍。
期刊介绍：
Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
