Global trends and regional differences in mortality of cardiovascular disease and its impact on longevity, 1980–2021: Age-period-cohort analyses and life expectancy decomposition based on the Global Burden of Disease study 2021

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-11-29 DOI:10.1016/j.arr.2024.102597

Xue Xia , Xue Tian , Qin Xu , Yijun Zhang , Xiaoli Zhang , Jing Li , Anxin Wang

{"title":"Global trends and regional differences in mortality of cardiovascular disease and its impact on longevity, 1980–2021: Age-period-cohort analyses and life expectancy decomposition based on the Global Burden of Disease study 2021","authors":"Xue Xia , Xue Tian , Qin Xu , Yijun Zhang , Xiaoli Zhang , Jing Li , Anxin Wang","doi":"10.1016/j.arr.2024.102597","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the temporal trend in cardiovascular disease (CVD) mortality and its impact on life expectancy (LE) gains across different Socio-demographic Index (SDI) regions.</div></div><div><h3>Methods</h3><div>Cause-specific mortality estimates during 1980–2021 were obtained from the Global Burden of Disease 2021 study. An age-period-cohort (APC) analysis was adopted to estimate the net/local drifts and the age/period/cohort effects of CVD mortality. CVD-specific contributions to LE gains were estimated with Arriaga’s method.</div></div><div><h3>Results</h3><div>The global age-standardized mortality rate of CVD declined remarkably from 416.1 to 235.2 per 100,000 during 1980–2021, with slight increase in the proportion of CVD death to all-cause mortality. The net drift of CVD mortality was −1.25 % per year during 1980–2019, and we observed negative local drifts across all age groups, among which middle-aged individuals experienced more rapid declines in CVD mortality than their younger counterparts. Favorable period and cohort effects were generally noted, particularly in high SDI countries. Globally, CVD mortality improvements accounted for an increase of 2.28 years (38.89 %) in LE at 20 years during 1980–2019, with relative contributions increasing from 15.18 % in low SDI region (mostly intracerebral hemorrhage) to 64.66 % in high SDI countries (mostly ischemic heart disease). Notably, LE gaps between low and high SDI countries further widened over study period, and the corresponding proportion attributable to CVD increased remarkably.</div></div><div><h3>Conclusion</h3><div>Process in reducing CVD mortality contributed to longevity improvements over the past four decades globally, with expanded cardiovascular health disparities across various SDI regions. More attention should be paid to CVD epidemic in low SDI countries to mitigate regional inequalities.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"103 ","pages":"Article 102597"},"PeriodicalIF":12.5000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ageing Research Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S156816372400415X","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To investigate the temporal trend in cardiovascular disease (CVD) mortality and its impact on life expectancy (LE) gains across different Socio-demographic Index (SDI) regions.

Methods

Cause-specific mortality estimates during 1980–2021 were obtained from the Global Burden of Disease 2021 study. An age-period-cohort (APC) analysis was adopted to estimate the net/local drifts and the age/period/cohort effects of CVD mortality. CVD-specific contributions to LE gains were estimated with Arriaga’s method.

Results

The global age-standardized mortality rate of CVD declined remarkably from 416.1 to 235.2 per 100,000 during 1980–2021, with slight increase in the proportion of CVD death to all-cause mortality. The net drift of CVD mortality was −1.25 % per year during 1980–2019, and we observed negative local drifts across all age groups, among which middle-aged individuals experienced more rapid declines in CVD mortality than their younger counterparts. Favorable period and cohort effects were generally noted, particularly in high SDI countries. Globally, CVD mortality improvements accounted for an increase of 2.28 years (38.89 %) in LE at 20 years during 1980–2019, with relative contributions increasing from 15.18 % in low SDI region (mostly intracerebral hemorrhage) to 64.66 % in high SDI countries (mostly ischemic heart disease). Notably, LE gaps between low and high SDI countries further widened over study period, and the corresponding proportion attributable to CVD increased remarkably.

Conclusion

Process in reducing CVD mortality contributed to longevity improvements over the past four decades globally, with expanded cardiovascular health disparities across various SDI regions. More attention should be paid to CVD epidemic in low SDI countries to mitigate regional inequalities.

查看原文本刊更多论文

1980-2021年心血管疾病死亡率的全球趋势和区域差异及其对寿命的影响：基于2021年全球疾病负担研究的年龄-时期队列分析和预期寿命分解

目的探讨不同社会人口指数（SDI）区域心血管疾病（CVD）死亡率的时间趋势及其对预期寿命（LE）增长的影响。方法1980-2021年期间的病因特异性死亡率估计来自2021年全球疾病负担研究。采用年龄-时期-队列（APC）分析来估计净/局部漂移和CVD死亡率的年龄/时期/队列效应。用Arriaga的方法估计了cvd对LE增益的特定贡献。结果1980-2021年，全球CVD年龄标准化死亡率从416.1 / 10万显著下降到235.2 / 10万，CVD死亡占全因死亡率的比例略有上升。在1980-2019年期间，CVD死亡率的净漂移为每年- 1.25 %，我们观察到所有年龄组的局部负漂移，其中中年人的CVD死亡率比年轻人下降得更快。普遍注意到有利的时期和队列效应，特别是在高SDI国家。在全球范围内，1980-2019年期间，心血管疾病死亡率的改善在20岁时增加了2.28年（38.89 %），相对贡献从低SDI地区的15.18 %（主要是脑出血）增加到高SDI国家的64.66 %（主要是缺血性心脏病）。值得注意的是，在研究期间，低SDI和高SDI国家之间的LE差距进一步扩大，相应的CVD比例显著增加。在过去的40年里，降低心血管疾病死亡率的过程促进了全球寿命的延长，不同SDI地区心血管健康差异扩大。应更多地关注低SDI国家的心血管疾病流行，以减轻区域不平等。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.