Survival outcomes of surgically treated oral cavity squamous cell carcinoma patients at tertiary care hospital in Northern Thailand.

IF 2.2 3区医学 Q2 Dentistry

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-11-26 DOI:10.1016/j.jormas.2024.102166

Tapanut Ariyanon, Hanpon Klibngern, Pichit Sittitrai, Donyarat Ruenmarkkaew, Weerachai Watcharatsiriyuth

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引用次数: 0

Abstract

Objective: This study aimed to evaluate the survival outcomes of surgically treated oral squamous cell carcinoma (OSCC) patients with or without adjuvant therapies and factors predicting treatment outcomes from the largest head and neck cancer center in Northern Thailand.

Methods: Two hundred and sixty OSCC patients curatively treated between 2017 and 2021 were retrospectively recruited into the study to analyze the clinicopathological characteristics and oncological outcomes and compare them with historical data. A multivariate Cox proportional hazards model analysis was performed to evaluate factors affecting survival outcomes.

Results: Males were slightly predominant (58.1 %). The most common subsite was an oral tongue (48.5 %), followed by an alveolar ridge (18.5 %). Advanced stages (III-IV) presented most at 88.5 %. The majority of the patients (52.3 %) received surgery and chemoradiotherapy, followed by surgery and radiotherapy (36.9 %), and surgery alone (10.8 %). The five-year overall survival (OS), disease-specific survival, and disease-free survival were 28.8 %, 44.0 %, and 46.3 %, respectively. Age > 45, ECOG performance status 2, and positive surgical margin status were found to be independent predictors for decreased OS (aHR 1.74, 95 % CI 1.01-3.00, aHR 2.64, 95 % CI 1.22-5.68, and aHR 1.76, 95 % CI 1.18-2.63, respectively).

Conclusions: Survival outcomes of OSCC in the study remain poor compared to other studies. The high prevalence of locally advanced stage presentation and inadequate surgical margin are the main problems. Public awareness, cancer screening programs, and intraoperative specimen-driven evaluation might help obtain adequate surgical margins and improve survival outcomes.

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泰国北部三级医院口腔鳞状细胞癌患者手术治疗后的生存结果

研究目的本研究旨在评估泰国北部最大的头颈部癌症中心接受或未接受辅助治疗的手术治疗口腔鳞状细胞癌（OSCC）患者的生存结果以及预测治疗结果的因素：研究回顾性招募了2017年至2021年间接受根治性治疗的260例OSCC患者，分析其临床病理特征和肿瘤学结果，并与历史数据进行比较。采用多变量Cox比例危险模型分析评估影响生存结果的因素：男性略占优势（58.1%）。最常见的部位是口腔舌（48.5%），其次是牙槽嵴（18.5%）。晚期（III-IV 期）患者最多，占 88.5%。大多数患者（52.3%）接受了手术和放化疗，其次是手术和放化疗（36.9%）以及单纯手术（10.8%）。五年总生存率（OS）、疾病特异性生存率和无病生存率分别为28.8%、44.0%和46.3%。研究发现，年龄大于45岁、ECOG表现为2级和手术切缘阳性是OS下降的独立预测因素（aHR分别为1.74，95% CI 1.01-3.00；aHR分别为2.64，95% CI 1.22-5.68；aHR分别为1.76，95% CI 1.18-2.63）：结论：与其他研究相比，本研究中OSCC的生存率仍然较低。结论：与其他研究相比，该研究中 OSCC 的生存率仍然较低，主要问题在于局部晚期和手术切缘不足。公众意识、癌症筛查计划和术中标本驱动评估可能有助于获得足够的手术切缘并改善生存结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.