Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation.

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2024-11-28 DOI:10.1002/jsfa.14045

Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór

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引用次数: 0

Abstract

Background: Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied. In addition, XO also takes part in the elimination of certain drugs, including 6-mercaptopurine. In the current explorative study, we aimed to examine the potential effects of tea catechins, resveratrol, silymarin flavonolignans and some of their conjugated metabolites on XO-catalyzed xanthine and 6-mercaptopurine oxidation, applying in vitro assays and modeling studies.

Results: Catechins, resveratrol and resveratrol conjugates exerted no or only weak inhibitory effects on XO. Silybin A, silybin B and isosilybin A were weak, silychristin was a moderate, while 2,3-dehydrosilychristin was a potent inhibitor of the enzyme. Sulfate metabolites of silybin A, silybin B and isosilybin A were considerably stronger inhibitors compared to the parent flavonolignans, and the sulfation of 2,3-dehydrosilychristin slightly increased its inhibitory potency. Silychristin was the sole flavonolignan tested, where sulfate conjugation decreased its inhibitory effect.

Conclusion: 2,3-Dehydrosilychristin seems to be a promising candidate for examining its in vivo antihyperuricemic effects, because both the parent compound and its sulfate conjugate are highly potent inhibitors of XO. © 2024 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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儿茶素、白藜芦醇、水飞蓟素成分及其部分共轭物对黄嘌呤氧化酶催化的黄嘌呤和 6-巯基嘌呤氧化的影响

背景：在过去二十年里，痛风的全球发病率显著上升，影响着全世界的人们。考虑到用于治疗高尿酸血症和痛风的黄嘌呤氧化酶（XO）抑制剂药物（如别嘌呤醇和非布索坦）的副作用，植物化学物质的潜在应用已被广泛研究。此外，XO 还参与了某些药物（包括 6-巯基嘌呤）的清除。在本次探索性研究中，我们旨在通过体外试验和模型研究，考察茶叶儿茶素、白藜芦醇、水飞蓟素黄酮木脂素及其部分共轭代谢物对 XO 催化的黄嘌呤和 6-巯基嘌呤氧化的潜在影响：结果：儿茶素、白藜芦醇和白藜芦醇共轭物对 XO 没有或只有微弱的抑制作用。水飞蓟宾 A、水飞蓟宾 B 和异水飞蓟宾 A 的抑制作用较弱，水飞蓟宾的抑制作用中等，而 2,3-脱氢水飞蓟宾是该酶的强效抑制剂。水飞蓟宾 A、水飞蓟宾 B 和异水飞蓟宾 A 的硫酸盐代谢物与母体黄酮木脂素相比具有更强的抑制作用，而 2,3-脱氢水飞蓟宾的硫酸盐化则略微提高了其抑制效力。结论：2,3-脱氢水飞蓟素似乎是研究其体内抗高尿酸血症作用的有希望的候选化合物，因为母体化合物及其硫酸盐共轭物都是强效的XO抑制剂。© 2024 作者。食品与农业科学杂志》由约翰威利父子有限公司代表化学工业协会出版。

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.