{"title":"Abietane Diterpenoids from the Rhizomes of <i>Kaempferia roscoeana</i> and Their Anti-Inflammatory Activities.","authors":"Ratchanaporn Chokchaisiri, Apinya Kaisoda, Sarot Cheenpracha, Lucksagoon Ganranoo, Sareeya Bureekaew, Chutamas Thepmalee, Apichart Suksamrarn","doi":"10.1021/acs.jnatprod.4c01127","DOIUrl":null,"url":null,"abstract":"<p><p>Six new abietane diterpenes, roscoeananes A-F (<b>1</b>-<b>6</b>), along with two known compounds (<b>7</b>-<b>8</b>) were isolated from the rhizomes of <i>Kaempferia roscoeana</i>. The structures of all compounds were elucidated by analysis of spectroscopic data, and the absolute configurations were assigned by a comparison of the theoretical and experimental electronic circular dichroism (ECD) spectra and a comparison with literature values. The unreported compound <b>5</b> is an ether-linked dimer of roscoeanane B (<b>2</b>). Most of the isolated compounds were tested for their nitric oxide inhibitory effects in lipopolysaccharide-activated RAW264.7 cells. Among them, roscoeanane A (<b>1</b>) was found to reduce NO levels in murine macrophage cells with an IC<sub>50</sub> value of 3.58 ± 0.95 μM and exhibited low cytotoxicity (IC<sub>50</sub> > 50 μM).</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1021/acs.jnatprod.4c01127","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Six new abietane diterpenes, roscoeananes A-F (1-6), along with two known compounds (7-8) were isolated from the rhizomes of Kaempferia roscoeana. The structures of all compounds were elucidated by analysis of spectroscopic data, and the absolute configurations were assigned by a comparison of the theoretical and experimental electronic circular dichroism (ECD) spectra and a comparison with literature values. The unreported compound 5 is an ether-linked dimer of roscoeanane B (2). Most of the isolated compounds were tested for their nitric oxide inhibitory effects in lipopolysaccharide-activated RAW264.7 cells. Among them, roscoeanane A (1) was found to reduce NO levels in murine macrophage cells with an IC50 value of 3.58 ± 0.95 μM and exhibited low cytotoxicity (IC50 > 50 μM).
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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