Prenatal chronic inflammation and children's executive function development.

IF 1.6 3区 心理学 Q3 CLINICAL NEUROLOGY
Iris Menu, Lanxin Ji, Christopher J Trentacosta, Suzanne M Jacques, Faisal Qureshi, Moriah E Thomason
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引用次数: 0

Abstract

Fetal inflammation, typically measured indirectly through prenatal maternal cytokine markers, has been shown to impact early childhood executive functions (EFs), which are central to later cognitive and life outcomes. Here, we assessed the impact of prenatal inflammation on EF developmental trajectories using direct placenta histopathology measures in 131 mothers who predominantly self-identified as Black (90.8% Black; 0.8% Asian American, 1.5% biracial, 0.8% Latinx, 3.1% White, 3.1% Missing). We found that placental measures of inflammation were associated with limited gain in EF development from 3 to 5 years old. In follow up analyses, we addressed whether screening questionnaires in infancy might aid in classification of infants as higher risk for subsequent EF problems. We found that parent responses to the Ages & Stages Questionnaire and the Infant/Toddler Sensory Profile at 12 months predict the development of EF abilities in children exposed to chronic inflammation. These findings open promising opportunities for early screening of children at risk for poor executive functioning in children exposed to prenatal inflammation.

产前慢性炎症与儿童执行功能的发展。
胎儿炎症通常通过产前母体细胞因子标记物间接测量,已被证明会影响儿童早期的执行功能(EFs),而执行功能是日后认知和生活结果的核心。在此,我们对 131 名主要自我认同为黑人(90.8% 黑人;0.8% 亚裔美国人;1.5% 双种族;0.8% 拉美裔;3.1% 白人;3.1% 失踪)的母亲进行了产前胎盘组织病理学测量,评估了产前炎症对 EF 发展轨迹的影响。我们发现,胎盘炎症指标与 3 至 5 岁幼儿 EF 发育的有限增长有关。在后续分析中,我们探讨了婴儿期的筛查问卷是否有助于将婴儿划分为后续出现心智发育问题的高风险人群。我们发现,12 个月大时家长对年龄与阶段问卷和婴幼儿感官档案的回答可以预测受到慢性炎症影响的儿童的EF能力发展。这些发现为早期筛查受产前炎症影响的儿童中存在执行功能低下风险的儿童提供了很好的机会。
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来源期刊
Child Neuropsychology
Child Neuropsychology 医学-临床神经学
CiteScore
4.10
自引率
9.10%
发文量
71
审稿时长
>12 weeks
期刊介绍: The purposes of Child Neuropsychology are to: publish research on the neuropsychological effects of disorders which affect brain functioning in children and adolescents, publish research on the neuropsychological dimensions of development in childhood and adolescence and promote the integration of theory, method and research findings in child/developmental neuropsychology. The primary emphasis of Child Neuropsychology is to publish original empirical research. Theoretical and methodological papers and theoretically relevant case studies are welcome. Critical reviews of topics pertinent to child/developmental neuropsychology are encouraged. Emphases of interest include the following: information processing mechanisms; the impact of injury or disease on neuropsychological functioning; behavioral cognitive and pharmacological approaches to treatment/intervention; psychosocial correlates of neuropsychological dysfunction; definitive normative, reliability, and validity studies of psychometric and other procedures used in the neuropsychological assessment of children and adolescents. Articles on both normal and dysfunctional development that are relevant to the aforementioned dimensions are welcome. Multiple approaches (e.g., basic, applied, clinical) and multiple methodologies (e.g., cross-sectional, longitudinal, experimental, multivariate, correlational) are appropriate. Books, media, and software reviews will be published.
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