Protective Contribution of Rosmarinic Acid in Rosemary Extract Against Copper-Induced Oxidative Stress.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2024-11-19 DOI:10.3390/antiox13111419

Arian Kola, Ginevra Vigni, Stefania Lamponi, Daniela Valensin

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引用次数: 0

Abstract

Rosemary extract (Rosmarinus officinalis) is a natural source of bioactive compounds with significant antioxidant properties. Among these, rosmarinic acid is celebrated for its potent antioxidant, anti-inflammatory, antimicrobial, and neuroprotective properties, making it a valuable component in both traditional medicine and modern therapeutic research. Neurodegenerative diseases like Alzheimer's and Parkinson's are closely linked to oxidative damage, and research indicates that rosmarinic acid may help protect neurons by mitigating this harmful process. Rosmarinic acid is able to bind cupric ions (Cu²⁺) and interfere with the production of reactive oxygen species (ROS) produced by copper through Fenton-like reactions. This study aims to further evaluate the contribution of rosmarinic acid within rosemary extract by comparing its activity to that of isolated rosmarinic acid. By using a detailed approach that includes chemical characterization, antioxidant capacity assessment, and neuroprotective activity testing, we have determined whether the combined components in rosemary extract enhance or differ from the effects of rosmarinic acid alone. This comparison is crucial for understanding whether the full extract offers added benefits beyond those of isolated rosmarinic acid in combating oxidative stress and Aβ-induced toxicity.

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迷迭香提取物中的迷迭香酸对铜诱导的氧化应激的保护作用

迷迭香提取物（Rosmarinus officinalis）是生物活性化合物的天然来源，具有显著的抗氧化特性。其中，迷迭香酸因其强大的抗氧化、抗炎、抗菌和神经保护特性而备受赞誉，成为传统医学和现代治疗研究中的重要成分。阿尔茨海默氏症和帕金森氏症等神经退行性疾病与氧化损伤密切相关，研究表明迷迭香酸可以通过减轻这一有害过程来保护神经元。迷迭香酸能够结合铜离子（Cu2+），并通过类似芬顿的反应干扰铜产生的活性氧（ROS）。本研究旨在通过比较迷迭香提取物与分离出的迷迭香酸的活性，进一步评估迷迭香酸在迷迭香提取物中的贡献。通过采用包括化学特征描述、抗氧化能力评估和神经保护活性测试在内的详细方法，我们确定了迷迭香提取物中的组合成分是否增强了迷迭香酸的作用，或者与单独迷迭香酸的作用有何不同。这种比较对于了解全提取物在对抗氧化应激和 Aβ 诱导的毒性方面是否比单独的迷迭香酸具有更多益处至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.