Oxidative Stress in an African Ground Squirrel, a Case of Healthy Aging and Reproduction.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Paul Juan Jacobs, Sjoerd Vos, Chelsea E Bishop, Daniel William Hart, Nigel Charles Bennett, Jane M Waterman
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Abstract

Oxidative stress plays a crucial role in mediating life-history processes, where it can compromise survival and reproduction through harmful alterations to DNA, lipids, and proteins. In this study, we investigated oxidative stress in Cape ground squirrels (Xerus inauris), a longer-lived African ground squirrel species with a high reproductive skew and unique life history strategies. We measured oxidative stress as total antioxidant capacity (TAC), total oxidant status (TOS), and an oxidative stress index (OSI) in blood plasma from individuals of approximately known ages. Our results reveal a distinct pattern of decreasing oxidative stress with age, consistent across both sexes. Females exhibited lower OSI and TOS levels than males. Males employing different life-history strategies, namely natal (staying at home), had significantly lower oxidative stress compared to the band (roaming male groups), likely due to variations in metabolic rate, activity, and feeding rates. However, both strategies exhibited reduced oxidative stress with age, though the underlying mechanisms require further investigation. We propose that selection pressures favoring survival contributed to the observed reduction in oxidative stress with age, potentially maximizing lifetime reproductive success in this species.

非洲地松鼠的氧化应激,一个健康老化和繁殖的案例。
氧化应激在介导生命史过程中起着至关重要的作用,它可以通过对 DNA、脂类和蛋白质的有害改变而影响生存和繁殖。在这项研究中,我们对开普地松鼠(Xerus inauris)的氧化应激进行了调查,开普地松鼠是一种寿命较长的非洲地松鼠物种,具有较高的繁殖斜率和独特的生活史策略。我们用总抗氧化能力(TAC)、总氧化状态(TOS)和氧化应激指数(OSI)测量了大约已知年龄个体血浆中的氧化应激。我们的研究结果表明,随着年龄的增长,氧化应激呈明显的下降趋势,这在男女两性中都是一致的。与雄性相比,雌性的 OSI 和 TOS 水平较低。采用不同生活史策略的雄性(即产仔(呆在家中))的氧化应激显著低于带状(漫游雄性群体),这可能是由于新陈代谢率、活动和摄食率的变化。不过,随着年龄的增长,这两种策略都表现出氧化应激的降低,但其潜在机制还需要进一步研究。我们认为,有利于生存的选择压力导致了氧化应激随年龄的增长而降低,从而可能使该物种的终生繁殖成功率最大化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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