Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth.

IF 3.1 2区 心理学 Q2 PSYCHOLOGY, DEVELOPMENTAL
Nadia Bounoua, Jane E Joseph, Zachary W Adams, Kathleen I Crum, Christopher T Sege, Lisa M McTeague, Greg Hajcak, Colleen A Halliday, Carla Kmett Danielson
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Abstract

The increased risk for psychopathology associated with interpersonal violence exposure (IPV, e.g., physical abuse, sexual assault) is partially mediated by neurobiological alterations in threat-related processes. Evidence supports parsing neural circuitry related to transient and sustained threat, as they appear to be separable processes with distinct neurobiological underpinnings. Although childhood is a sensitive period for neurodevelopment, most prior work has been conducted in adult samples. Further, it is unknown how IPV exposure may impact transient-sustained threat neural interactions. The current study tested the moderating role of IPV exposure on sustained vmPFC-transient amygdala co-activation during an fMRI task during which threat and neutral cues were predictably or unpredictably presented. Analyses were conducted in a sample of 212 community-recruited youth (M/SDage = 11.77/2.44 years old; 51.9% male; 56.1% White/Caucasian). IPV-exposed youth evidenced a positive sustained vmPFC-transient amygdala co-activation, while youth with no IPV exposure did not show this association. Consistent with theoretical models, effects were specific to unpredictable, negative trials and to exposure to IPV (i.e., unrelated to non-IPV traumatic experiences). Although preliminary, these findings provide novel insight into how childhood IPV exposure may alter neural circuity involved in specific facets of threat processing.

社区青少年样本中的人际暴力调节了大脑前部皮层和杏仁核中持续-瞬时威胁的共同激活。
与人际暴力(IPV,如身体虐待、性侵犯)相关的精神病理学风险的增加部分是由威胁相关过程的神经生物学改变介导的。有证据支持解析与瞬时威胁和持续威胁相关的神经回路,因为它们似乎是可分离的过程,具有不同的神经生物学基础。虽然童年是神经发育的敏感期,但之前的大多数研究都是在成人样本中进行的。此外,IPV 暴露如何影响瞬时-持续威胁的神经交互作用尚不清楚。本研究测试了 IPV 暴露对在威胁和中性线索可预测或不可预测呈现的 fMRI 任务中持续的 vmPFC-瞬时杏仁核共同激活的调节作用。分析是在 212 名社区招募的青少年样本中进行的(M/SD 年龄 = 11.77/2.44 岁;51.9% 为男性;56.1% 为白人/高加索人)。接触过 IPV 的青少年表现出正向持续的大脑前部-瞬时杏仁核共同激活,而没有接触过 IPV 的青少年则没有表现出这种关联。与理论模型相一致的是,这种效应是针对不可预测的负面试验和接触过 IPV(即与非 IPV 的创伤经历无关)而产生的。这些发现虽然是初步的,但却为我们提供了新的视角,让我们了解童年时期受到的 IPV 可能会如何改变威胁处理过程中特定方面的神经环路。
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来源期刊
Development and Psychopathology
Development and Psychopathology PSYCHOLOGY, DEVELOPMENTAL-
CiteScore
7.20
自引率
9.10%
发文量
319
期刊介绍: This multidisciplinary journal is devoted to the publication of original, empirical, theoretical and review papers which address the interrelationship of normal and pathological development in adults and children. It is intended to serve and integrate the field of developmental psychopathology which strives to understand patterns of adaptation and maladaptation throughout the lifespan. This journal is of interest to psychologists, psychiatrists, social scientists, neuroscientists, paediatricians, and researchers.
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