Sarcopenia and the biological determinants of aging: A narrative review from a geroscience perspective

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-11-19 DOI:10.1016/j.arr.2024.102587

Mariá Nunes-Pinto , Renato Gorga Bandeira de Mello , Milena Nunes Pinto , Cédric Moro , Bruno Vellas , Laurent O. Martinez , Yves Rolland , Philipe de Souto Barreto

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Abstract

Background

The physiopathology of sarcopenia shares common biological cascades with the aging process, as does any other age-related condition. However, our understanding of the interconnected pathways between diagnosed sarcopenia and aging remains limited, lacking sufficient scientific evidence.

Methods

This narrative review aims to gather and describe the current evidence on the relationship between biological aging determinants, commonly referred to as the hallmarks of aging, and diagnosed sarcopenia in humans.

Results

Among the twelve hallmarks of aging studied, there appears to be a substantial association between sarcopenia and mitochondrial dysfunction, epigenetic alterations, deregulated nutrient sensing, and altered intercellular communication. Although limited, preliminary evidence suggests a promising association between sarcopenia and genomic instability or stem cell exhaustion.

Discussion

Overall, an imbalance in energy regulation, characterized by impaired mitochondrial energy production and alterations in circulatory markers, is commonly associated with sarcopenia and may reflect the interplay between aging physiology and sarcopenia biology.

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肌肉疏松症与衰老的生物学决定因素：从地球科学的角度进行叙述性回顾。

背景：与其他与年龄有关的疾病一样，肌肉疏松症的生理病理与衰老过程有着共同的生物级联。然而，我们对已确诊的肌肉疏松症与衰老之间相互关联的途径的了解仍然有限，缺乏足够的科学证据：本叙述性综述旨在收集和描述有关生物衰老决定因素（通常称为衰老标志）与人类确诊肌肉疏松症之间关系的现有证据：结果：在所研究的 12 个衰老标志中，肌肉疏松症似乎与线粒体功能障碍、表观遗传学改变、营养传感失调和细胞间通讯改变有很大关系。尽管证据有限，但初步证据表明，肌肉疏松症与基因组不稳定性或干细胞衰竭之间存在密切联系：总之，能量调节失衡（以线粒体能量生成受损和循环标志物改变为特征）通常与肌肉疏松症有关，可能反映了衰老生理学与肌肉疏松症生物学之间的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.